ArticleScientific reports2017
Serum prealbumin and its changes over time are associated with mortality in acute kidney injury.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Expert Consensus on Morphofunctional Assessment in Disease-Related Malnutrition. Grade Review and Delphi Study.Nutrients · 2023Pooled it
- Protein-Energy Wasting Assessment and Clinical Outcomes in Patients with Acute Kidney Injury: A Systematic Review with Meta-Analysis.Nutrients · 2020Pooled it
- Retinol-binding protein 4 (RBP4) and prealbumin (PA) serum concentration and bioimpedance parameters as selected markers of nutritional status in children with nephrotic syndrome.BMC nephrology · 2025Article
- Exploring the potential of blood and urine protein electrophoresis in predicting 1-year mortality in acute kidney injury.PloS one · 2025Article
- Transthyretin and Nutritional Status in Critically Ill Adults on Parenteral Nutrition: A Prospective Cohort Study.Nutrients · 2024Article
- Association of prealbumin with short-term and long-term outcomes in patients with acute ST-segment elevation myocardial infarction.Journal of geriatric cardiology : JGC · 2024Article
- Nutritional Biomarkers as Predictors of Dysphonia Severity in Patients with Ischemic Stroke.Nutrients · 2023Article
- Article
- Combined serum free light chain predicts prognosis in acute kidney injury following cardiovascular surgery.Renal failure · 2022Article
- Evolving Concepts on Inflammatory Biomarkers and Malnutrition in Chronic Kidney Disease.Nutrients · 2022Review
- Common and Novel Markers for Measuring Inflammation and Oxidative Stress Ex Vivo in Research and Clinical Practice-Which to Use Regarding Disease Outcomes?Antioxidants (Basel, Switzerland) · 2021Review
- Decreased prealbumin level is associated with increased risk for mortality in elderly hospitalized patients with COVID-19.Nutrition (Burbank, Los Angeles County, Calif.) · 2020Article
- Indoxyl sulfate is associated with mortality after AKI - more evidence needed!BMC nephrology · 2019Article
- Review
- Association of prealbumin levels with contrast-induced acute kidney injury in elderly patients with elective percutaneous coronary intervention.Clinical interventions in aging · 2018Article
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9 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Serum prealbumin is a clinically relevant indicator of nutritional status and inflammation in patients with acute kidney injury (AKI). This study aimed to determine whether serum prealbumin and its longitudinal changes over a week could improve the prediction of 90-day mortality in AKI patients. This prospective cohort study included 340 adults with AKI between 2014 and 2015. There were 94 (27.6%) patient deaths within 90 days. Serum prealbumin level <10 mg/dL at the time of AKI diagnosis was associated with a 155% increased death risk ratio (adjusted hazard ratio [HR], 2.55; 95% confidence interval [CI], 1.18 to 5.49; P = 0.02). Serum prealbumin fall >4 mg/dL was also associated with 90-day mortality in adjusted Cox regression models (HR, 1.79; 95% CI, 1.06 to 3.03; P = 0.03). Compared to serum albumin, mortality-predictability of serum prealbumin (P = 0.01) and its changes (P = 0.01) were both increased. Adding prealbumin and its changes on the conventional covariates improved the prediction of progression to 90-day mortality (NRI 0.29, P = 0.04; aIDI 0.08; P = 0.03). In conclusion, serum prealbumin, and its changes were independent predictors of worse prognosis in AKI, and could be potential surrogates to better predict 90-day mortality.
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