Evidence map›Paper›PMID 28145439›Full record

ReviewMucosal immunology2017

Evolutionary and ecological forces that shape the bacterial communities of the human gut.

J S Messer, E R Liechty, O A Vogel, E B Chang

Abstract readReview
In one paragraph

Review in Mucosal immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Whole-genome and pan-genome analyses reveal genomic differences among nontypeableFrontiers in cellular and infection microbiology · 2026
    Article
  5. Article
  6. Draft genome sequence of the emerging fish pathogenMicrobiology resource announcements · 2023
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

J S MesserThe Department of Medicine, The University of Chicago, Chicago, Illinois, USA.
E R LiechtyNorthwestern University, Chicago, Illinois, USA.
O A VogelThe Department of Medicine, The University of Chicago, Chicago, Illinois, USA.
E B ChangThe Department of Medicine, The University of Chicago, Chicago, Illinois, USA.

Funding

ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 1990 to 2025
$29.8M
Mutualistic relationship between Hsp25/27 and gut microbes as a major and essential determinant of mucosal healing and microbial fitness following intestinal injuryR01DK047722 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 1993 to 2020
$4.3M
Cytoprotective Role of Heat Shock Proteins in IBDR37DK047722 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 2008 to 2017
$3.8M
Dietary fat effects on gut microbes, host immune state and experimental colitisR01DK097268 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 2012 to 2016
$2.2M
NIDDK NIH HHS P30 DK042086NIDDK NIH HHS R01 DK047722NIDDK NIH HHS R01 DK097268NIDDK NIH HHS R37 DK047722
6 · The paper itself

Abstract

Since microbes were first described in the mid-1600s, we have come to appreciate that they live all around and within us with both beneficial and detrimental effects on nearly every aspect of our lives. The human gastrointestinal tract is inhabited by a dynamic community of trillions of bacteria that constantly interact with each other and their human host. The acquisition of these bacteria is not stochastic but determined by circumstance (environment), host rules (genetics, immune state, mucus, etc), and dynamic self-selection among microbes to form stable, resilient communities that are in balance with the host. In this review, we will discuss how these factors lead to formation of the gut bacterial community and influence its interactions with the host. We will also address how gut bacteria contribute to disease and how they could potentially be targeted to prevent and treat a variety of human ailments.

Indexed as

BacteriaBiological EvolutionGastrointestinal MicrobiomeEnvironmental ExposureGastrointestinal TractHomeostasisHost-Pathogen InteractionsHumansImmunity, MucosalIntestinal Diseases

Identifiers

PMID28145439
PMCPMC5700752

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.