ArticleNature communications2017
β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions.
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Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48 citing papers in PubMed, 77 citations in OpenAlex.
- Review
- Mice lacking β-arrestin-2 in melanocortin 4 receptor-expressing neurons show marked metabolic deficits.JCI insight · 2026Article
- From metabolic regulation to kidney protection: β-arrestin 2 as a dual-function therapeutic target.World journal of diabetes · 2025Article
- G-Protein-Coupled Receptor (GPCR) Signaling and Pharmacology in Metabolism: Physiology, Mechanisms, and Therapeutic Potential.Biomolecules · 2025Review
- Extracellular matrix from decellularized porcine organs as scaffolds for insulin-secreting cells and pancreatic islets.Frontiers in endocrinology · 2025Article
- Development of Novel Tools for Dissection of Central Versus Peripheral Dopamine D2-Like Receptor Signaling in Dysglycemia.Diabetes · 2024Article
- Intra-islet α-cell Gs signaling promotes glucagon release.Nature communications · 2024Article
- GLP1R and GIPR expression and signaling in pancreatic alpha cells, beta cells and delta cells.Peptides · 2024Article
- The Role of G Protein-Coupled Receptors and Receptor Kinases in PancreaticPharmacological reviews · 2024Review
- Association of Neurokinin-1 Receptor Signaling Pathways with Cancer.Current medicinal chemistry · 2024Review
- Review
- Divergent acute versus prolonged pharmacological GLP-1R responses in adult β cell-specific β-arrestin 2 knockout mice.Science advances · 2023Article
- GLP-1R Signaling and Functional Molecules in Incretin Therapy.Molecules (Basel, Switzerland) · 2023Review
- Roles of Pancreatic Islet Catecholamine Neurotransmitters in Glycemic Control and in Antipsychotic Drug-Induced Dysglycemia.Diabetes · 2023Review
- Imidacloprid Impairs Glutamatergic Synaptic Plasticity and Desensitizes Mechanosensitive, Nociceptive, and Photogenic Response ofInternational journal of molecular sciences · 2022Article
- Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine.iScience · 2022Article
- Intracellular ATP Signaling Contributes to FAM3A-Induced PDX1 Upregulation in Pancreatic Beta Cells.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2022Article
- 14-3-3ζ Constrains insulin secretion by regulating mitochondrial function in pancreatic β cells.JCI insight · 2022Article
- Mechanistic Investigation of GHS-R Mediated Glucose-Stimulated Insulin Secretion in Pancreatic Islets.Biomolecules · 2022Article
- The therapeutic potential of GLP-1 receptor biased agonism.British journal of pharmacology · 2022 · on this mapReview
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Authors and funding
23 authors at 8 institutions in 2 countries.
Lu ZhuMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA.
Joana AlmaçaDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
Prasanna K DadiDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, USA.
Hao HongMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA.
Wataru SakamotoMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA.
Mario RossiMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA.
Regina J LeeMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA.
Nicholas C VierraDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, USA.
Huiyan LuMouse Transgenic Core Facility, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA.
Yinghong CuiMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA.
Sara M McMillinMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA.
Nicole A PerryDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA.
Vsevolod V GurevichDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA.ORCID 0000-0002-3950-5351
Amy LeeDepartment of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, USA.
Bryan KuoLaboratory of Bioengineering and Physical Science, National Institute of Biomedical Imaging and Bioengineering, Bethesda, Maryland 20892, USA.
Richard D LeapmanLaboratory of Bioengineering and Physical Science, National Institute of Biomedical Imaging and Bioengineering, Bethesda, Maryland 20892, USA.
Franz M MatschinskyDepartment of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennslvania 19104, USA.
Nicolai M DolibaDepartment of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennslvania 19104, USA.
Nikhil M UrsDepartment of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Marc G CaronDepartment of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.
David A JacobsonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, USA.
Alejandro CaicedoDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
Jürgen WessMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA.
National Institute of Diabetes and Digestive and Kidney Diseases · USVanderbilt University · USDuke University · USNational Institute of Biomedical Imaging and Bioengineering · USUniversity of Miami · USUniversity of Pennsylvania · USNanjing University of Chinese Medicine · CNUniversity of Iowa · US
Funding
VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL A. LAZAR · 1986 to 2026
$48.3MRole of G protein-coupled receptors in regulating glucose and energy homeostasisZIADK075021 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI WESS, JURGEN · 2009 to 2025
$37.0MThree-Dimensional Cell and Tissue Reconstruction by Serial Block Face SEMZIAEB000086 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI LEAPMAN, RICHARD · 2013 to 2025
$23.6MSTRUCTURE/FUNCTION STUDIES OF VISUAL ARRESTINR01EY011500 · NEI · VANDERBILT UNIVERSITY · PI T M Iverson · 1997 to 2026
$12.3MAkt/GSK-3 Signaling Cascade and the Actions of DopamineR37MH073853 · NIMH · DUKE UNIVERSITY · PI CARON, MARC G. · 2011 to 2020
$6.4MRegulation of auditory calcium channelsR01DC009433 · NIDCD · UNIVERSITY OF IOWA · PI LEE, AMY · 2009 to 2018
$3.6MTwo-Pore-Domain Potassium Channels as Novel Targets for Modulating Islet Hormone SecretionR01DK097392 · NIDDK · VANDERBILT UNIVERSITY · PI JACOBSON, DAVID AARON · 2013 to 2022
$3.3MTargeted Engineering of Designer Arrestins to Regulate Cell SignalingR35GM122491 · NIGMS · VANDERBILT UNIVERSITY · PI GUREVICH, VSEVOLOD V. · 2017 to 2021
$2.6MArrestin interactions with non-receptor binding partnersR01GM077561 · NIGMS · VANDERBILT UNIVERSITY · PI GUREVICH, VSEVOLOD V. · 2007 to 2015
$2.3MRegulation of Neuronal Calcium ChannelsR01NS084190 · NINDS · UNIVERSITY OF IOWA · PI LEE, AMY · 2014 to 2018
$2.2MThe Role of Innervation for Hormone Secretion in Human IsletsR01DK084321 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CAICEDO, ALEJANDRO · 2011 to 2015
$1.8MCholinergic signaling in the human pancreatic isletR01DK111538 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CAICEDO, ALEJANDRO · 2016 to 2018
$1.2MNEI NIH HHS R01 EY011500NIDCD NIH HHS R01 DC009433NIDDK NIH HHS K01 DK081666NIDDK NIH HHS K01 DK111757NIDDK NIH HHS P30 DK019525NIDDK NIH HHS R01 DK084321NIDDK NIH HHS R01 DK097392NIDDK NIH HHS R01 DK111538NIDDK NIH HHS R56 DK084321NIEHS NIH HHS R21 ES025673NIGMS NIH HHS R01 GM077561NIGMS NIH HHS R01 GM109955NIGMS NIH HHS R35 GM122491NIMH NIH HHS R37 MH073853NINDS NIH HHS R01 NS084190
Abstract
β-arrestins are critical signalling molecules that regulate many fundamental physiological functions including the maintenance of euglycemia and peripheral insulin sensitivity. Here we show that inactivation of the β-arrestin-2 gene, barr2, in β-cells of adult mice greatly impairs insulin release and glucose tolerance in mice fed with a calorie-rich diet. Both glucose and KCl-induced insulin secretion and calcium responses were profoundly reduced in β-arrestin-2 (barr2) deficient β-cells. In human β-cells, barr2 knockdown abolished glucose-induced insulin secretion. We also show that the presence of barr2 is essential for proper CAMKII function in β-cells. Importantly, overexpression of barr2 in β-cells greatly ameliorates the metabolic deficits displayed by mice consuming a high-fat diet. Thus, our data identify barr2 as an important regulator of β-cell function, which may serve as a new target to improve β-cell function.
Indexed as
Animalsbeta-Arrestin 2Calcium-Calmodulin-Dependent Protein Kinase Type 2Cell LineCell Line, TumorDiet, High-FatGene ExpressionHumansInsulinInsulin-Secreting CellsInsulin SecretionIslets of LangerhansMice, Inbred C57BLMice, KnockoutMice, TransgenicSignal Transductionbeta-Arrestin 2Calcium-Calmodulin-Dependent Protein Kinase Type 2Insulin
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