Changes in serum osmotic pressure following haemodialysis treatments lead to changes in bioimpedance spectroscopy estimates of lean and adipose tissue.

M Antonelou, S El-Kateb, N Davies, A Davenport

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Article in European journal of clinical nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

M AntonelouUCL Centre for Nephrology, University College London Institute for Liver and Digestive Health, University College London Medical School, Royal Free Hospital, London, UK.

S El-KatebUCL Centre for Nephrology, University College London Institute for Liver and Digestive Health, University College London Medical School, Royal Free Hospital, London, UK.

N DaviesLiver Failure Group, University College London Institute for Liver and Digestive Health, University College London Medical School, Royal Free Hospital, London, UK.

A DavenportUCL Centre for Nephrology, University College London Institute for Liver and Digestive Health, University College London Medical School, Royal Free Hospital, London, UK.

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No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Haemodialysis (HD) patients are at risk of sarcopenia. Newer bioimpedance devices (BIS) using a three-compartmental body composition model, separate extracellular water overhydration from normo-hydrated lean tissue mass (LTM) and adipose tissue mass (ATM). During HD hydration status changes, along with changes in electrolytes and solutes, and may alter body composition measurements. As such, we measured BIS and serum osmotic pressure (sOP) pre- and post dialysis in 43 patients. There were no significant changes in LTM (39.5±15.1 vs 39.3±15.2 kg) or sOP (33.2±8.3 vs 35.9±9.7 mm Hg). Higher post-dialysis sOP was associated with a greater percentage fall in LTM (r=0.43, P=0.08) and increase in ATM (r=-0.43, P=0.017). Increased sOP post dialysis was associated with a reduction in LTM (r=0.36, P=0.033) and increased ATM (r=-0.44, P=0.013). Changes in sOP with HD are associated with changes in BIS body composition measurements. BIS measurements should preferably be made when patients are least overhydrated.

Indexed as

Adipose TissueAgedBody CompositionDielectric SpectroscopyFemaleHumansKidney DiseasesMaleMiddle AgedOrganism Hydration StatusOsmotic PressureRenal DialysisSarcopenia

Identifiers

PMID28145415

DOI10.1038/ejcn.2016.270

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