ArticleHuman brain mapping2017
Gray matter heritability in family-based and population-based studies using voxel-based morphometry.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- [Research progress on genetic effects of the asymmetry of human brain structure revealed by magnetic resonance imaging].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Pooled it
- Imaging-genetics-based dementia risk prediction using deep survival neural networks in the Rotterdam Study.Scientific reports · 2026Article
- Heritability of gray matter volume and asymmetry in chimpanzees (Pan troglodytes) and their association to cognitive abilities and tool use.Brain structure & function · 2025Article
- Imaging-genetics-based dementia risk prediction using deep survival neural networks in the Rotterdam Study.Research square · 2025Article
- Intergenerational transmission of brain structure and function in humans: a narrative review of designs, methods, and findings.Brain structure & function · 2024Review
- LearningBrain sciences · 2023Article
- Efficient Pairwise Neuroimage Analysis Using the Soft Jaccard Index and 3D Keypoint Sets.IEEE transactions on medical imaging · 2022Article
- Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Article
- Shared genetic influences on adolescent body mass index and brain structure: A voxel-based morphometry study in twins.NeuroImage · 2019Article
- Neuroimaging-informed phenotypes of suicidal behavior: a family history of suicide and the use of a violent suicidal means.Translational psychiatry · 2018Article
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13 authors.
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Abstract
backgroundThe combination of genetics and imaging has improved their understanding of the brain through studies of aggregate measures obtained from high-resolution structural imaging. Voxel-wise analyses have the potential to provide more detailed information of genetic influences on the brain. Here they report a large-scale study of the heritability of gray matter at voxel resolution (1 × 1 × 1 mm).
methodsValidated voxel-based morphometry (VBM) protocols were applied to process magnetic resonance imaging data of 3,239 unrelated subjects from a population-based study and 491 subjects from two family-based studies. Genome-wide genetic data was used to estimate voxel-wise gray matter heritability of the unrelated subjects and pedigree-structure was used to estimate heritability in families. They subsequently associated two genetic variants, known to be linked with subcortical brain volume, with most heritable voxels to determine if this would enhance their association signals.
resultsVoxels significantly heritable in both estimates mapped to subcortical structures, but also voxels in the language areas of the left hemisphere were found significantly heritable. When comparing regional patterns of heritability, family-based estimates were higher than population-based estimates. However, regional consistency of the heritability measures across study designs was high (Pearson's correlation coefficient = 0.73, P = 2.6 × 10
conclusionGray matter voxel-wise heritability can be reliably estimated with different methods. Combining heritability estimates from multiple studies is feasible to construct reliable heritability maps of gray matter voxels. Hum Brain Mapp 38:2408-2423, 2017. © 2017 Wiley Periodicals, Inc.
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