ArticleThe journal of headache and pain2017
Volume gain of periaqueductal gray in medication-overuse headache.
Article in The journal of headache and pain, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Advances of neuroimaging findings in medication overuse headache.Frontiers in neuroscience · 2025Review
- Hypoperfusion of hypothalamic subunits in medication-overuse headache using a 3D PCASL MRI.Scientific reports · 2024Article
- The role of the brainstem in sleep disturbances and chronic pain of Gulf War and Iraq/Afghanistan veterans.Frontiers in molecular neuroscience · 2023Article
- Altered metabolites in the periaqueductal gray of COVID-19 patients experiencing headaches: a longitudinal MRS study.Frontiers in neurology · 2023Article
- Medication overuse headache and substance use disorder: A comparison based on basic research and neuroimaging.Frontiers in neurology · 2023Review
- Serotonin 1B receptor density mapping of the human brainstem using positron emission tomography and autoradiography.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Article
- Impact of Medical Care on Symptomatic Drug Consumption and Quality of Life in Headache: A One-Year Population Study.Frontiers in neurology · 2019Article
- Volume Gain of Brainstem on Medication-Overuse Headache Using Voxel-Based Morphometry.Chinese medical journal · 2018Article
- The journey from genetic predisposition to medication overuse headache to its acquisition as sequela of chronic migraine.The journal of headache and pain · 2018Article
- Alteration of gray matter texture features over the whole brain in medication-overuse headache using a 3-dimentional texture analysis.The journal of headache and pain · 2017Article
- Volume expansion of periaqueductal gray in episodic migraine: a pilot MRI structural imaging study.The journal of headache and pain · 2017Article
- Volumetric abnormalities of thalamic subnuclei in medication-overuse headache.The journal of headache and pain · 2017Article
- Lower hippocampal subfields volume in relation to anxiety in medication-overuse headache.Molecular painArticle
- Review
- Morphometric changes over the whole brain in caffeine-containing combination-analgesic-overuse headache.Molecular painArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeriaqueductal gray (PAG) is a substantial descending pain modulatory center, and previous voxel-based morphometry study confirmed the clusters with increased volume in PAG region in medication-overuse headache (MOH). The aim of this study is to investigate altered PAG volume in MOH using an automated PAG segment method to measure the true PAG volume.
methodsHigh resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MR images were obtained from 22 patients with MOH and 22 normal controls (NC). PAG template was created based on ICBM 152 gray template, and the individual PAG was generated by applying the deformation field from structural image segment to the PAG template, and individual PAG volume was calculated.
resultsThere was a significant increased volume of PAG in MOH (0.366 ± 0.005 ml) than that in NC (0.341 ± 0.005 ml)(P < 0.05). There was no significant correlation between the PAG volume and the clinical variables in MOH patients (P > 0.05). The area of receiver operating characteristic (ROC) curve was 0.845, and the cut-off of PAG volume was 0.341 ml with sensitivity 95.5% and specificity 63.6%.
conclusionThe present study demonstrated that the PAG volume gain was confirmed in MOH patients, and the automated individual PAG volume measure may be considered as a simple and effective imaging biomarker in MOH diagnosis.
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