ArticleeNeuro
Modulation of Rhythmic Activity in Mammalian Spinal Networks Is Dependent on Excitability State.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Article
- Episodic rhythmicity is generated by a distributed neural network in the developing mammalian spinal cord.iScience · 2025Article
- Multistability of bursting rhythms in a half-center oscillator and the protective effects of synaptic inhibition.Frontiers in cellular neuroscience · 2024Article
- Limiting Monoamines Degradation Increases L-DOPA Pro-Locomotor Action in Newborn Rats.International journal of molecular sciences · 2023Article
- The Consistency of Gastropod Identified Neurons Distinguishes Intra-Individual Plasticity From Inter-Individual Variability in Neural Circuits.Frontiers in behavioral neuroscience · 2022Review
- Automated analyses for single-fiber electrophysiological recordings using a newly developed Microsoft Excel application and graphical user interface.Journal of neuroscience methods · 2021Article
- Comodulation of h- and NaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Repetitive optogenetic stimulation of glutamatergic neurons: An alternative to NMDA treatment for generating locomotor activity in spinalized zebrafish larvae.Physiological reports · 2021Article
- Contributions of h- and NaFrontiers in cellular neuroscience · 2021Article
- The serotonin reuptake blocker citalopram destabilizes fictive locomotor activity in salamander axial circuits through 5-HTJournal of neurophysiology · 2020Article
- Serotonergic Modulation of Locomotor Activity From Basal Vertebrates to Mammals.Frontiers in neural circuits · 2020Review
- Glutamate receptor subtypes differentially contribute to optogenetically activated swimming in spinally transected zebrafish larvae.Journal of neurophysiology · 2019Article
- Balanced cholinergic modulation of spinal locomotor circuits via M2 and M3 muscarinic receptors.Scientific reports · 2019Article
- Persistent effects of cyclic adenosine monophosphate are directly responsible for maintaining a neural network state.Scientific reports · 2019Article
- A supervised machine learning approach to characterize spinal network function.Journal of neurophysiology · 2019Article
- Locomotor-related V3 interneurons initiate and coordinate muscles spasms after spinal cord injury.Journal of neurophysiology · 2019Article
- Stepping responses to treadmill perturbations vary with severity of motor deficits in human SCI.Journal of neurophysiology · 2018Article
- Retracing your footsteps: developmental insights to spinal network plasticity following injury.Journal of neurophysiology · 2018Review
- Optogenetic Activation of A11 Region Increases Motor Activity.Frontiers in neural circuits · 2018Article
- Integration of Descending Command Systems for the Generation of Context-Specific Locomotor Behaviors.Frontiers in neuroscience · 2017Review
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Authors and funding
2 authors.
Funding
Abstract
Neuromodulators play an important role in activating rhythmically active motor networks; however, what remains unclear are the network interactions whereby neuromodulators recruit spinal motor networks to produce rhythmic activity. Evidence from invertebrate systems has demonstrated that the effect of neuromodulators depends on the pre-existing state of the network. We explored how network excitation state affects the ability of dopamine to evoke rhythmic locomotor activity in the neonatal mouse isolated spinal cord. We found that dopamine can evoke unique patterns of motor activity that are dependent on the excitability state of motor networks. Different patterns of motor activity ranging from tonic, nonrhythmic activity to multirhythmic, nonlocomotor activity to locomotor activity were produced by altering global motor network excitability through manipulations of the extracellular potassium and bath NMDA concentration. A similar effect was observed when network excitation was manipulated during an unstable multirhythm evoked by a low concentration (15 µm) of 5-HT, suggesting that our results are not neuromodulator specific. Our data show in vertebrate systems that modulation is a two-way street and that modulatory actions are largely influenced by the network state. The level of network excitation can account for variability between preparations and is an additional factor to be considered when circuit elements are removed from the network.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.