Evidence map›Paper›PMID 28144536›Full record

ArticleBeilstein journal of nanotechnology2016

Low temperature co-fired ceramic packaging of CMOS capacitive sensor chip towards cell viability monitoring.

Niina Halonen, Joni Kilpijärvi, Maciej Sobocinski, Timir Datta-Chaudhuri, Antti Hassinen, Someshekar B Prakash, Peter Möller, Pamela Abshire, Sakari Kellokumpu, Anita Lloyd Spetz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Beilstein journal of nanotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Niina HalonenMicroelectronics Research Unit, Faculty of Information Technology and Electrical Engineering, P.O.Box 4500, FI-90014 University of Oulu, Finland.
Joni KilpijärviMicroelectronics Research Unit, Faculty of Information Technology and Electrical Engineering, P.O.Box 4500, FI-90014 University of Oulu, Finland.
Maciej SobocinskiMicroelectronics Research Unit, Faculty of Information Technology and Electrical Engineering, P.O.Box 4500, FI-90014 University of Oulu, Finland.
Timir Datta-ChaudhuriDepartment of Electrical & Computer Engineering and the Institute for Systems Research, University of Maryland, College Park, MD 20742, USA.
Antti HassinenFaculty of Biochemistry and Molecular Medicine, University of Oulu, P.O. Box 5400, FI-90014 University of Oulu, Finland.
Someshekar B PrakashDepartment of Electrical & Computer Engineering and the Institute for Systems Research, University of Maryland, College Park, MD 20742, USA; Advanced Design Organization, Intel Corporation, Hillsboro, USA.
Peter MöllerDivision of Applied Sensor Science, Department of Physics, Chemistry and Biology, Linköping University, SE-58183 Linköping, Sweden.
Pamela AbshireDepartment of Electrical & Computer Engineering and the Institute for Systems Research, University of Maryland, College Park, MD 20742, USA.
Sakari KellokumpuFaculty of Biochemistry and Molecular Medicine, University of Oulu, P.O. Box 5400, FI-90014 University of Oulu, Finland.
Anita Lloyd SpetzMicroelectronics Research Unit, Faculty of Information Technology and Electrical Engineering, P.O.Box 4500, FI-90014 University of Oulu, Finland; Division of Applied Sensor Science, Department of Physics, Chemistry and Biology, Linköping University, SE-58183 Linköping, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell viability monitoring is an important part of biosafety evaluation for the detection of toxic effects on cells caused by nanomaterials, preferably by label-free, noninvasive, fast, and cost effective methods. These requirements can be met by monitoring cell viability with a capacitance-sensing integrated circuit (IC) microchip. The capacitance provides a measurement of the surface attachment of adherent cells as an indication of their health status. However, the moist, warm, and corrosive biological environment requires reliable packaging of the sensor chip. In this work, a second generation of low temperature co-fired ceramic (LTCC) technology was combined with flip-chip bonding to provide a durable package compatible with cell culture. The LTCC-packaged sensor chip was integrated with a printed circuit board, data acquisition device, and measurement-controlling software. The packaged sensor chip functioned well in the presence of cell medium and cells, with output voltages depending on the medium above the capacitors. Moreover, the manufacturing of microfluidic channels in the LTCC package was demonstrated.

Indexed as

capacitance sensingcell viabilitylab-on-a-chiplow temperature co-fired ceramic (LTCC)

Identifiers

PMID28144536
PMCPMC5238666

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.