ArticleAsian journal of sports medicine2016
Effect of Treadmill Running on Morphine Dependence Before and After Medial Prefrontal Cortex Lesion in Rats.
Article in Asian journal of sports medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Aerobic exercise as a promising nonpharmacological therapy for the treatment of substance use disorders.Journal of neuroscience research · 2022Review
- Increased sign-tracking behavior in adolescent rats.Developmental psychobiology · 2017Article
- Physical Exercise Interventions for Drug Addictive Disorders.Journal of reward deficiency syndrome and addiction science · 2017Article
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Authors and funding
2 authors.
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Abstract
backgroundPrevious studies on the medial prefrontal cortex (mPFC) has shown that this area plays an important role in addiction behavior. Other studies also indicated that exercise decreases use of morphine.
objectivesThe aim of this study was to evaluate the effects of short-term exercise on trends for use of morphine with an intact mPFC and lesion of that area.
methods50 rats randomly were selected and divided into 5 groups. 1-exercise. 2- Morphine + Lesion. 3- Morphine + Exercise + Lesion. 4- Morphine. 5- Morphine and Exercise. All groups received morphine for 9 days except exercise group. On the 10th day, the symptoms of addiction were evaluated. To determine the effects of exercise, a treadmill apparatus was used for exercising.
resultsOur results indicated that exercise with intact mPFC area significantly decreased the tendency of using morphine which is verified by changes in symptoms (P < 0.05), but after a lesion of this area exercise did not significantly affect these withdrawal symptoms.
conclusionsIt seems that a lesion of mPFC area significantly reduced the effect of short-term exercise on the usage pattern of morphine.
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