ArticleBeilstein journal of organic chemistry2016
The digital code driven autonomous synthesis of ibuprofen automated in a 3D-printer-based robot.
Article in Beilstein journal of organic chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Additive Manufacturing in Organic Chemistry: From Synthesis to Sustainable Process Design.International journal of molecular sciences · 2026Review
- Chemputer and chemputation-A universal chemical compound synthesis machine.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A robotic system for automated chemical synthesis of therapeutic agents.Materials advances · 2024Article
- 3D printing processes in precise drug delivery for personalized medicine.Biofabrication · 2024Review
- Robotic Modules for the Programmable Chemputation of Molecules and Materials.ACS central science · 2023Review
- Toward the Uniform of Chemical Theory, Simulation, and Experiments in Metaverse Technology.Precision chemistry · 2023Review
- The Evolution of the 3D-Printed Drug Delivery Systems: A Review.Pharmaceutics · 2022Review
- Review
- Miau, a microbalance autosampler.HardwareX · 2021Article
- Open-hardware wireless controller and 3D-printed pumps for efficient liquid manipulation.HardwareX · 2021Article
- Current and future trends of additive manufacturing for chemistry applications: a review.Journal of materials science · 2021Review
- Fused Deposition Modeling 3D Printing: Test Platforms for Evaluating Post-Fabrication Chemical Modifications and In-Vitro Biological Properties.Pharmaceutics · 2019Article
- Networking chemical robots for reaction multitasking.Nature communications · 2018Article
- The Molecular Industrial Revolution: Automated Synthesis of Small Molecules.Angewandte Chemie (International ed. in English) · 2018Review
- Improvement of quality of 3D printed objects by elimination of microscopic structural defects in fused deposition modeling.PloS one · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An automated synthesis robot was constructed by modifying an open source 3D printing platform. The resulting automated system was used to 3D print reaction vessels (reactionware) of differing internal volumes using polypropylene feedstock via a fused deposition modeling 3D printing approach and subsequently make use of these fabricated vessels to synthesize the nonsteroidal anti-inflammatory drug ibuprofen via a consecutive one-pot three-step approach. The synthesis of ibuprofen could be achieved on different scales simply by adjusting the parameters in the robot control software. The software for controlling the synthesis robot was written in the python programming language and hard-coded for the synthesis of ibuprofen by the method described, opening possibilities for the sharing of validated synthetic 'programs' which can run on similar low cost, user-constructed robotic platforms towards an 'open-source' regime in the area of chemical synthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.