Evidence map›Paper›PMID 28144152›Full record

ArticleOncoTargets and therapy2017

Overall survival in renal cell carcinoma after introduction of targeted therapies: a Norwegian population-based study.

Christian Beisland, Tom B Johannesen, Olbjorn Klepp, Ulrika Axcrona, Knut Martin Torgersen, Jan Kowalski, Oddvar Solli, Rickard Sandin, Jan Oldenburg

Abstract read
In one paragraph

Article in OncoTargets and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christian BeislandDepartment of Urology, Haukeland University Hospital; Department of Clinical Medicine, University of Bergen, Bergen.
Tom B JohannesenDepartment of Registration, Cancer Registry of Norway, Oslo.
Olbjorn KleppDepartment of Oncology, Ålesund Hospital, Ålesund.
Ulrika AxcronaDepartment of Pathology, Oslo University Hospital, the Norwegian Radium Hospital, Oslo.
Knut Martin TorgersenPfizer AS, Oslo, Norway.
Jan KowalskiJK Biostatistics AB, Stockholm.
Oddvar SolliPfizer AS, Oslo, Norway.
Rickard SandinPfizer AB, Sollentuna, Sweden.
Jan OldenburgDepartment of Oncology, Akershus University Hospital, Lørenskog; Medical Faculty, University of Oslo, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis population-wide retrospective, non-interventional registry study assessed changes in overall survival (OS) and factors influencing OS in Norwegian patients with renal cell carcinoma (RCC).

methodsTwo population-wide health registries were used to identify all RCC patients with (mRCC) or without metastases diagnosed before (2002-2005) and after (2006-2008 and 2009-2011) introduction of targeted therapies. Median OS was estimated using Kaplan-Meier method. Cox proportional hazards regression modeling was used to identify prognostic factors.

resultsOverall, 5,463 patients were diagnosed with RCC during 2002-2005 (n=1,898), 2006-2008 (n=1,631), and 2009-2011 (n=1,934); of these, 1,678 (31%) had mRCC. Patients diagnosed in 2009-2011 and 2006-2008 had significant (

conclusionOS increased in RCC and mRCC patients in Norway between 2002 and 2011 following introduction of targeted therapies.

Indexed as

nephrectomyNorwayoverall survivalrenal cell carcinomatargeted therapy

Identifiers

PMID28144152
PMCPMC5248939

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.