Evidence map›Paper›PMID 28144031›Full record

ReviewNature reviews. Molecular cell biology2017

RNA modifications and structures cooperate to guide RNA-protein interactions.

Cole J T Lewis, Tao Pan, Auinash Kalsotra

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Molecular cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 184 papers.

0numbers the graph read from it
0cells of the map it votes in
184citing papers in PubMed
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

184 citing papers in PubMed, 309 citations in OpenAlex.

  1. Article
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  12. Subtype-Specific mInternational journal of molecular sciences · 2026
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  14. Comprehensive discovery of mNature communications · 2025
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  16. TheiScience · 2025
    Article
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124 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Cole J T LewisDepartment of Biochemistry, University of Illinois.
Tao PanDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, USA.
Auinash KalsotraDepartment of Biochemistry, University of Illinois.
University of Illinois Urbana-Champaign · USUniversity of Chicago · US

Funding

Post-transcriptional mechanisms of gene regulation in cardiac cell growth and developmentR01HL126845 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KALSOTRA, AUINASH · 2015 to 2023
$3.5M
Recognition and mechanism of N6-methyl adenosine modificationsR01GM113194 · NIGMS · UNIVERSITY OF CHICAGO · PI PAN, TAO · 2015 to 2022
$2.5M
NHLBI NIH HHS R01 HL126845NIGMS NIH HHS R01 GM113194
6 · The paper itself

Abstract

An emerging body of evidence indicates that post-transcriptional gene regulation relies not only on the sequence of mRNAs but also on their folding into intricate secondary structures and on the chemical modifications of the RNA bases. These features, which are highly dynamic and interdependent, exert direct control over the transcriptome and thereby influence many aspects of cell function. Here, we consider how the coupling of RNA modifications and structures shapes RNA-protein interactions at different steps of the gene expression process.

Indexed as

Nucleic Acid ConformationProtein BiosynthesisProteinsProtein SplicingRNA, Guide, CRISPR-Cas SystemsRNA, MessengerRNA StabilityProteinsRNA, Guide, CRISPR-Cas SystemsRNA, Messenger

Identifiers

PMID28144031
PMCPMC5542016
OpenAlexW2585466487

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.