Evidence map›Paper›PMID 28143955›Full record

ArticleThe Journal of experimental medicine2017

The Eph-related tyrosine kinase ligand Ephrin-B1 marks germinal center and memory precursor B cells.

Brian J Laidlaw, Timothy H Schmidt, Jesse A Green, Christopher D C Allen, Takaharu Okada, Jason G Cyster

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 121 citations in OpenAlex.

  1. Article
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  5. Article
  6. The multilayered identity of B cell memory.Cellular & molecular immunology · 2026
    Review
  7. Importance of B cells (Review).International journal of molecular medicine · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Polarization of the memory B-cell response.Journal of leukocyte biology · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Brian J LaidlawDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143.
Timothy H SchmidtDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143.ORCID 0000-0003-3991-0012
Jesse A GreenDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143.
Christopher D C AllenDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143.ORCID 0000-0002-1879-9047
Takaharu OkadaLaboratory for Tissue Dynamics, Institute of Physical and Chemical Research Center for Integrative Medical Sciences (IMS-RCAI), Yokohama, Kanagawa 230-0045, Japan.
Jason G CysterDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143 jason.cyster@ucsf.edu.ORCID 0000-0002-4735-9745
Howard Hughes Medical Institute · USRIKEN Center for Integrative Medical Sciences · JPUniversity of California, San Francisco · US

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 2003 to 2019
$21.8M
INTERDISCIPLINARY IMMUNOLOGY TRAINING PROGRAMT32AI007019 · NIAID · YALE UNIVERSITY · PI Carrie L. Lucas, David G. Schatz · 1985 to 2026
$14.4M
MOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0M
Chemokines and Lymphoid Tissue Organization and FunctionR01AI045073 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1999 to 2023
$7.6M
B LYMPHOCYTE MIGRATION AND HOMEOSTASISR01AI040098 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jason G Cyster · 1997 to 2026
$7.0M
Chemokines and Lymphoid Tissue Organization and FunctionR37AI045073 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jason G Cyster · 2024 to 2026
$1.7M
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI040098NIAID NIH HHS R01 AI045073NIAID NIH HHS R37 AI045073NIAID NIH HHS T32 AI007019NIAID NIH HHS T32 AI007334NIDDK NIH HHS P30 DK063720
6 · The paper itself

Abstract

Identification of germinal center (GC) B cells is typically reliant on the use of surface activation markers that exhibit a wide range of expression. Here, we identify Ephrin-B1, a ligand for Eph-related receptor tyrosine kinases, as a specific marker of mature GC B cells. The number of Ephrin-B1

Indexed as

Immunologic MemoryAnimalsBiomarkersB-LymphocytesEphrin-B1Germinal CenterMiceMice, Inbred C57BLReceptors, LysosphingolipidSphingosine-1-Phosphate ReceptorsSyndecan-1BiomarkersEphrin-B1Receptors, LysosphingolipidSdc1 protein, mousesphingosine-1-phosphate receptor-2, mouseSphingosine-1-Phosphate ReceptorsSyndecan-1

Identifiers

PMID28143955
PMCPMC5339677
OpenAlexW2583285089

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.