Evidence map›Paper›PMID 28143879›Full record

ReviewEuropean respiratory review : an official journal of the European Respiratory Society2017

Acute high-altitude sickness.

Andrew M Luks, Erik R Swenson, Peter Bärtsch

Registry-linked trialOpen access · diamondAbstract readReview
In one paragraph

Review in European respiratory review : an official journal of the European Respiratory Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06446427 (The Effect of Acute High Altitude Exposure on Rescuer Performance and Patient Care), which is not on this map. Cited by 240 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
240citing papers in PubMed, 3 pooled it
24.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06446427 nacompletednot on this mapstarted 2024, after this paper: background citation

The Effect of Acute High Altitude Exposure on Rescuer Performance and Patient Care

TypeinterventionalSponsorInsel Gruppe AG, University Hospital BernRan2024 to 2025Enrolled20ConditionsHigh Altitude, Hypobaric Hypoxia, Risk ReductionArmsAcute high altitude exposure, Acute high altitude exposure, with supplementary oxygen, Subacute high altitude exposure, after having spent a night at high altitude
3 · Its place in the literature

Who cites it

240 citing papers in PubMed, 3 syntheses or guidelines pooled it, 489 citations in OpenAlex.

  1. Pooled it
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  11. Cardiometabolic Risk Factors in Women Exposed to High Altitude.International journal of molecular sciences · 2026
    Review
  12. Acclimatization Effects ofInternational journal of molecular sciences · 2026
    Article
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180 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Andrew M LuksDept of Medicine, Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, USA aluks@u.washington.edu.
Erik R SwensonDept of Medicine, Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, USA.
Peter BärtschDept of Internal Medicine, University Clinic Heidelberg, Heidelberg, Germany.
University of Washington · USHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

At any point 1-5 days following ascent to altitudes ≥2500 m, individuals are at risk of developing one of three forms of acute altitude illness: acute mountain sickness, a syndrome of nonspecific symptoms including headache, lassitude, dizziness and nausea; high-altitude cerebral oedema, a potentially fatal illness characterised by ataxia, decreased consciousness and characteristic changes on magnetic resonance imaging; and high-altitude pulmonary oedema, a noncardiogenic form of pulmonary oedema resulting from excessive hypoxic pulmonary vasoconstriction which can be fatal if not recognised and treated promptly. This review provides detailed information about each of these important clinical entities. After reviewing the clinical features, epidemiology and current understanding of the pathophysiology of each disorder, we describe the current pharmacological and nonpharmacological approaches to the prevention and treatment of these diseases.

Indexed as

AltitudeCerebrovascular CirculationPulmonary CirculationVasoconstrictionAcute DiseaseAdultAgedAltitude SicknessAnimalsBrain EdemaCerebral ArteriesFemaleHumansHypertension, PulmonaryHypoxiaInflammation

Identifiers

PMID28143879
PMCPMC9488514
OpenAlexW2584358852

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.