Evidence map›Paper›PMID 28143855›Full record

ReviewAmerican journal of physiology. Endocrinology and metabolism2017

"Nutraceuticals" in relation to human skeletal muscle and exercise.

Colleen S Deane, Daniel J Wilkinson, Bethan E Phillips, Kenneth Smith, Timothy Etheridge, Philip J Atherton

Open access · greenAbstract readReview
In one paragraph

Review in American journal of physiology. Endocrinology and metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 73 citations in OpenAlex.

  1. Trial
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  7. The Possible Roles ofCurrent medicinal chemistry · 2025
    Review
  8. Review
  9. Skeletal muscle dysfunction with advancing age.Clinical science (London, England : 1979) · 2024
    Review
  10. Article
  11. A proprietary blend ofFood & nutrition research · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Sestrins in Physiological Stress Responses.Annual review of physiology · 2021
    Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Colleen S DeaneMedical Research Council-Arthritis Research UK Centre of Excellence for Musculoskeletal Ageing Research and Clinical, Metabolic, and Molecular Physiology, University of Nottingham, Royal Derby Hospital, Derby, United Kingdom.
Daniel J WilkinsonMedical Research Council-Arthritis Research UK Centre of Excellence for Musculoskeletal Ageing Research and Clinical, Metabolic, and Molecular Physiology, University of Nottingham, Royal Derby Hospital, Derby, United Kingdom.
Bethan E PhillipsMedical Research Council-Arthritis Research UK Centre of Excellence for Musculoskeletal Ageing Research and Clinical, Metabolic, and Molecular Physiology, University of Nottingham, Royal Derby Hospital, Derby, United Kingdom.
Kenneth SmithMedical Research Council-Arthritis Research UK Centre of Excellence for Musculoskeletal Ageing Research and Clinical, Metabolic, and Molecular Physiology, University of Nottingham, Royal Derby Hospital, Derby, United Kingdom.
Timothy EtheridgeDepartment of Sport and Health Science, College of Life and Environmental Sciences, University of Exeter, Exeter, United Kingdom.
Philip J AthertonMedical Research Council-Arthritis Research UK Centre of Excellence for Musculoskeletal Ageing Research and Clinical, Metabolic, and Molecular Physiology, University of Nottingham, Royal Derby Hospital, Derby, United Kingdom; philip.atherton@nottingham.ac.uk.
Royal Derby Hospital · GBBournemouth University · GBMedical Research Council · GBUniversity of Exeter · GBVersus Arthritis · GB

Funding

Medical Research Council MR/K00414X/1Medical Research Council MR/P021220/1Versus Arthritis 19891
6 · The paper itself

Abstract

Skeletal muscles have a fundamental role in locomotion and whole body metabolism, with muscle mass and quality being linked to improved health and even lifespan. Optimizing nutrition in combination with exercise is considered an established, effective ergogenic practice for athletic performance. Importantly, exercise and nutritional approaches also remain arguably the most effective countermeasure for muscle dysfunction associated with aging and numerous clinical conditions, e.g., cancer cachexia, COPD, and organ failure, via engendering favorable adaptations such as increased muscle mass and oxidative capacity. Therefore, it is important to consider the effects of established and novel effectors of muscle mass, function, and metabolism in relation to nutrition and exercise. To address this gap, in this review, we detail existing evidence surrounding the efficacy of a nonexhaustive list of macronutrient, micronutrient, and "nutraceutical" compounds alone and in combination with exercise in relation to skeletal muscle mass, metabolism (protein and fuel), and exercise performance (i.e., strength and endurance capacity). It has long been established that macronutrients have specific roles and impact upon protein metabolism and exercise performance, (i.e., protein positively influences muscle mass and protein metabolism), whereas carbohydrate and fat intakes can influence fuel metabolism and exercise performance. Regarding novel nutraceuticals, we show that the following ones in particular may have effects in relation to

Indexed as

Dietary SupplementsAthletic PerformanceExerciseHumansMuscle, SkeletalNutritional StatusPhysical Enduranceexercisemetabolismnutraceuticalsnutrientsskeletal muscle

Identifiers

PMID28143855
PMCPMC5406990
OpenAlexW2583161188

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.