ReviewAgeing research reviews2017
Risk of cardiovascular disease morbidity and mortality in frail and pre-frail older adults: Results from a meta-analysis and exploratory meta-regression analysis.
Review in Ageing research reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
141 citing papers in PubMed, 11 syntheses or guidelines pooled it, 288 citations in OpenAlex.
- The effect of expressive writing intervention for patients with reproductive trauma on anxiety, depression and stress: a meta-analysis of randomized controlled trials.BMC pregnancy and childbirth · 2026Pooled it
- Association between pre-stroke frailty status and stroke risk and impact on outcomes: a systematic review and meta-analysis of 1,660,328 participants.Aging clinical and experimental research · 2024Pooled it
- Systematic Review of the Association of the Hospital Frailty Risk Score with Mortality in Patients with Cerebrovascular and Cardiovascular Disease.Current cardiology reviews · 2024Pooled it
- Frailty and risks of all-cause and cause-specific death in community-dwelling adults: a systematic review and meta-analysis.BMC geriatrics · 2022Pooled it
- Association between frailty and ischemic heart disease: a systematic review and meta-analysis.BMC geriatrics · 2021Pooled it
- Cognition and Frailty in Patients With Heart Failure: A Systematic Review of the Association Between Frailty and Cognitive Impairment.Frontiers in psychiatry · 2021Pooled it
- Pooled it
- Prognostic value of frailty in elderly patients with acute coronary syndrome: a systematic review and meta-analysis.BMC geriatrics · 2019Pooled it
- Relationship between frailty and mortality, hospitalization, and cardiovascular diseases in diabetes: a systematic review and meta-analysis.Cardiovascular diabetology · 2019Pooled it
- Frailty as a Predictor of Cognitive Disorders: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2019Pooled it
- Pooled it
- Invasive vs Conservative Strategy for Frail Older Patients With Myocardial Infarction: A Secondary Analysis of the SENIOR-RITA Randomized Clinical Trial.JAMA network open · 2026Trial
- Trial
- The association between mobility and asleep blood pressure alterations in frail and non-frail adults 80 years and older.Journal of human hypertension · 2026Article
- Cardiovascular frailty - an emerging frailty phenotype.Journal of human hypertension · 2026Review
- Perspectives on cardiovascular longevity and economic prosperity in the Association of Southeast Asian Nations (ASEAN).npj aging · 2026Article
- Frailty before disease onset: risk of mortality and chronic conditions in disease-free middle-aged adults.GeroScience · 2026Article
- Gut microbiota associates with frailty in older women.Nature communications · 2026Article
- Sugar rationing in the first 1000 days of life and risk of frailty: evidence from a natural experiment.The journal of nutrition, health & aging · 2026Article
- TyG Index and Frailty as Composite Biomarkers of Cardiometabolic Risk and Mortality Across CKM Stages 0-3.Metabolites · 2026Article
81 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 19 institutions in 8 countries.
Funding
Abstract
Frailty is common and associated with poorer outcomes in the elderly, but its role as potential cardiovascular disease (CVD) risk factor requires clarification. We thus aimed to meta-analytically evaluate the evidence of frailty and pre-frailty as risk factors for CVD. Two reviewers selected all studies comparing data about CVD prevalence or incidence rates between frail/pre-frail vs. robust. The association between frailty status and CVD in cross-sectional studies was explored by calculating and pooling crude and adjusted odds ratios (ORs) ±95% confidence intervals (CIs); the data from longitudinal studies were pooled using the adjusted hazard ratios (HRs). Eighteen cohorts with a total of 31,343 participants were meta-analyzed. Using estimates from 10 cross-sectional cohorts, both frailty and pre-frailty were associated with higher odds of CVD than robust participants. Longitudinal data were obtained from 6 prospective cohort studies. After a median follow-up of 4.4 years, we identified an increased risk for faster onset of any-type CVD in the frail (HR=1.70 [95%CI, 1.18-2.45]; I
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.