SynthesisMechanisms of ageing and development2017
Limitations and risks of meta-analyses of longevity studies.
Synthesis in Mechanisms of ageing and development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- A systematic review and meta-analyses of the association between 4 mycoplasma species and lower respiratory tract disease in dogs.Journal of veterinary internal medicine · 2019Pooled it
- A meta-analysis of genome-wide association studies identifies multiple longevity genes.Nature communications · 2019Pooled it
- APOE Alleles and Extreme Human Longevity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Pooled it
- Effects of FOXO3 Polymorphisms on Survival to Extreme Longevity in Four Centenarian Studies.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Pooled it
- Evolutionary genetics of ageing.Nature reviews. Genetics · 2026Review
- Climbing the longevity pyramid: overview of evidence-driven healthcare prevention strategies for human longevity.Frontiers in aging · 2024Review
- A Genome-Wide Association Study of 2304 Extreme Longevity Cases Identifies Novel Longevity Variants.International journal of molecular sciences · 2022Article
- How Important Are Genes to Achieve Longevity?International journal of molecular sciences · 2022Review
- Genetic signature of human longevity in PKC and NF-κB signaling.Aging cell · 2021Article
- Article
- Redox-mediated regulation of aging and healthspan by an evolutionarily conserved transcription factor HLH-2/Tcf3/E2A.Redox biology · 2020Article
- A serum protein signature of APOE genotypes in centenarians.Aging cell · 2019Article
- PopCluster: an algorithm to identify genetic variants with ethnicity-dependent effects.Bioinformatics (Oxford, England) · 2019Article
- Genetic and epigenetic regulation of human aging and longevity.Biochimica et biophysica acta. Molecular basis of disease · 2019Review
- Artificial Intelligence Based Approaches to Identify Molecular Determinants of Exceptional Health and Life Span-An Interdisciplinary Workshop at the National Institute on Aging.Frontiers in artificial intelligence · 2019Review
- Report: NIA workshop on translating genetic variants associated with longevity into drug targets.GeroScience · 2018Article
- Analysis of Polymorphisms in 59 Potential Candidate Genes for Association With Human Longevity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- Impact of demography and population dynamics on the genetic architecture of human longevity.Aging · 2018Article
- Genetics of exceptional longevity: possible role of GM allotypes.Immunity & ageing : I & A · 2018Article
- FOXO3 and Exceptional Longevity: Insights From Hydra to Humans.Current topics in developmental biology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Searching for genetic determinants of human longevity has been challenged by the rarity of data sets with large numbers of individuals who have reached extreme old age, inconsistent definitions of the phenotype, and the difficulty of defining appropriate controls. Meta-analysis - a statistical method to summarize results from different studies - has become a common tool in genetic epidemiology to accrue large sample sizes for powerful genetic association studies. In conducting a meta-analysis of studies of human longevity however, particular attention must be made to the definition of cases and controls (including their health status) and on the effect of possible confounders such as sex and ethnicity upon the genetic effect to be estimated. We will show examples of how a meta-analysis can inflate the false negative rates of genetic association studies or it can bias estimates of the association between a genetic variant and extreme longevity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.