Observational studyBMC pulmonary medicine2017
Airway wall thickness on HRCT scans decreases with age and increases with smoking.
Observational study in BMC pulmonary medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00848406 (An Observational Study to Obtain Normal Values of Inflammatory Variables in Induced Sputum, Exhaled Breath, and Bronchial Biopsies From Healthy Smoking and Non-smoking Individuals), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Observational Study to Obtain Normal Values of Inflammatory Variables in Induced Sputum, Exhaled Breath, and Bronchial Biopsies From Healthy Smoking and Non-smoking Individuals
Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Relationship between coughing and bispectral index-guided sedation during pulsed field ablation for atrial fibrillation and its impact on mid-term outcomes.Heart rhythm O2 · 2026Article
- Detection of Airway Remodeling in Asthma Using Bronchoscopic Optical Coherence Tomography.CHEST pulmonary · 2025Article
- Reporting and management of incidental lung findings on computed tomography: beyond lung nodules.The British journal of radiology · 2023Review
- MDCT-based longitudinal automated airway and air trapping analysis in school-age children with mild cystic fibrosis lung disease.Frontiers in pediatrics · 2023Article
- AI-Supported Comprehensive Detection and Quantification of Biomarkers of Subclinical Widespread Diseases at Chest CT for Preventive Medicine.Healthcare (Basel, Switzerland) · 2022Article
- Quantitative imaging analysis detects subtle airway abnormalities in symptomatic military deployers.BMC pulmonary medicine · 2022Article
- Review
- Fully integrating pathophysiological insights in COPD: an updated working disease model to broaden therapeutic vision.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Increased myofibroblasts in the small airways, and relationship to remodelling and functional changes in smokers and COPD patients: potential role of epithelial-mesenchymal transition.ERJ open research · 2021Article
- Tenascin-C: Friend or Foe in Lung Aging?Frontiers in physiology · 2021Article
- Smooth-muscle-derived WNT5A augments allergen-induced airway remodelling and Th2 type inflammation.Scientific reports · 2020Article
- Longitudinal airway remodeling in active and past smokers in a lung cancer screening population.European radiology · 2019Article
- Age-related gene and miRNA expression changes in airways of healthy individuals.Scientific reports · 2019Article
- Cardiopulmonary and Muscular Interactions: Potential Implications for Exercise (In)tolerance in Symptomatic Smokers Without Chronic Obstructive Pulmonary Disease.Frontiers in physiology · 2019Review
- Serum periostin does not reflect type 2-driven inflammation in COPD.Respiratory research · 2018Article
- Standardized airway wall thickness Pi10 from routine CT scans of COPD patients as imaging biomarker for disease severity, lung function decline, and mortality.Therapeutic advances in respiratory diseaseArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate if age, gender and smoking are associated with airway wall thickness (AWT) measured by high resolution computed tomography (HRCT) and if higher AWT is associated with lower levels of pulmonary function in healthy current- and never-smokers with a wide age range.
methodsHRCT scans were performed in 99 subjects (48 never- and 51 current-smokers, median age 39 years [IQR 22 - 54], 57% males). The AWT at an internal perimeter of 10 mm (AWT Pi10) was calculated as an overall measurement of AWT, based on all measurements throughout the lungs. Extensive pulmonary function testing was performed in all subjects.
resultsHigher age was associated with a lower AWT Pi10 (b = -0.003, p < 0.001). Current-smokers had a higher AWT Pi10 than never-smokers (mean 0.49 mm versus 0.44 mm, p = 0.022). In multivariate analysis, age and current-smoking were independently associated with AWT Pi10 (age b = -0.002, p < 0.001, current-smoking b = 0.041, p = 0.021), whereas gender was not (b = 0.011, p = 0.552). Higher AWT Pi10 was associated with a lower FEV
conclusionsAWT decreases with higher age, possibly reflecting structural changes of the airways. Additionally, current-smokers have a higher AWT, possibly due to remodeling or inflammation. Finally, higher AWT is associated with a lower level of pulmonary function, even in this population of healthy subjects.
trial registrationThis Study was registered at www.clinicaltrials.gov with number NCT00848406 on 19 February 2009.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.