ArticleChinese journal of cancer2017
The most important questions in cancer research and clinical oncology-Question 2-5. Obesity-related cancers: more questions than answers.
Article in Chinese journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The relationship between loneliness, psychological resilience, quality of life and taste change in cancer patients receiving chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Progranulin: A proangiogenic factor in visceral adipose tissue in tumoral and non-tumoral visceral pathology.Experimental and therapeutic medicine · 2021Article
- The Troubling Link Between Non-alcoholic Fatty Liver Disease (NAFLD) and Extrahepatic Cancers (EHC).Cureus · 2021Review
- Pleiotropic genomic variants at 17q21.31 associated with bone mineral density and body fat mass: a bivariate genome-wide association analysis.European journal of human genetics : EJHG · 2021Article
- The 150 most important questions in cancer research and clinical oncology series: questions 94-101 : Edited by Cancer Communications.Cancer communications (London, England) · 2018Article
- Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine.Gut · 2018Review
- The 150 most important questions in cancer research and clinical oncology series: questions 86-93 : Edited by Chinese Journal of Cancer.Chinese journal of cancer · 2018Article
- The 150 most important questions in cancer research and clinical oncology series: questions 76-85 : Edited by Chinese Journal of Cancer.Chinese journal of cancer · 2017Article
- The 150 most important questions in cancer research and clinical oncology series: questions 67-75 : Edited by Chinese Journal of Cancer.Chinese journal of cancer · 2017Article
- The 150 most important questions in cancer research and clinical oncology series: questions 57-66 : Edited by Chinese Journal of Cancer.Chinese journal of cancer · 2017Article
- The 150 most important questions in cancer research and clinical oncology series: questions 50-56.Chinese journal of cancer · 2017Article
- The 150 most important questions in cancer research and clinical oncology series: questions 40-49.Chinese journal of cancer · 2017Article
- The 150 most important questions in cancer research and clinical oncology series: questions 31-39 : Edited by Chinese Journal of Cancer.Chinese journal of cancer · 2017Article
- The 150 most important questions in cancer research and clinical oncology series: Questions 25-30 : Edited by Chinese Journal of Cancer.Chinese journal of cancer · 2017Article
- The 150 most important questions in cancer research and clinical oncology series: questions 6-14 : Edited by Chinese Journal of Cancer.Chinese journal of cancer · 2017Article
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Abstract
Obesity is recognized as the second highest risk factor for cancer. The pathogenic mechanisms underlying tobacco-related cancers are well characterized and effective programs have led to a decline in smoking and related cancers, but there is a global epidemic of obesity without a clear understanding of how obesity causes cancer. Obesity is heterogeneous, and approximately 25% of obese individuals remain healthy (metabolically healthy obese, MHO), so which fat deposition (subcutaneous versus visceral, adipose versus ectopic) is "malignant"? What is the mechanism of carcinogenesis? Is it by metabolic dysregulation or chronic inflammation? Through which chemokines/genes/signaling pathways does adipose tissue influence carcinogenesis? Can selective inhibition of these pathways uncouple obesity from cancers? Do all obesity related cancers (ORCs) share a molecular signature? Are there common (over-lapping) genetic loci that make individuals susceptible to obesity, metabolic syndrome, and cancers? Can we identify precursor lesions of ORCs and will early intervention of high risk individuals alter the natural history? It appears unlikely that the obesity epidemic will be controlled anytime soon; answers to these questions will help to reduce the adverse effect of obesity on human condition.
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