Evidence map›Paper›PMID 28143511›Full record

ArticleBMC veterinary research2017

A novel Salmonella strain inactivated by a regulated autolysis system and expressing the B subunit of Shiga toxin 2e efficiently elicits immune responses and confers protection against virulent Stx2e-producing Escherichia coli.

Gayeon Won, Tae Hoon Kim, John Hwa Lee

Open access · goldAbstract read
In one paragraph

Article in BMC veterinary research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. The Preventive Effect ofOxidative medicine and cellular longevity · 2021
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Gayeon WonCollege of Veterinary Medicine, Chonbuk National University, Iksan campus, Gobong-ro 79, Iksan, 54596, Republic of Korea.
Tae Hoon KimCollege of Veterinary Medicine, Chonbuk National University, Iksan campus, Gobong-ro 79, Iksan, 54596, Republic of Korea.
John Hwa LeeCollege of Veterinary Medicine, Chonbuk National University, Iksan campus, Gobong-ro 79, Iksan, 54596, Republic of Korea. johnhlee@jbnu.ac.kr.
Jeonbuk National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSalmonella Typhimurium (S. Typhimurium) inactivated by a regulated autolysis system was genetically engineered to express the homo-pentameric B subunit of Shiga toxin 2e (Stx2eB) on its surface. To prepare a strain able to yield autolyzed Salmonella bearing Stx2eB, the plasmid pJHL184 harboring stx

conclusionsJOL1454 provided superior immunogenicity and effective protection against challenge with a sublethal dose, which demonstrates its potential as a candidate vaccine against edema disease.

Indexed as

AnimalsCell ProliferationCytokinesEscherichia coliEscherichia coli InfectionsEscherichia coli VaccinesFemaleImmunity, CellularImmunity, HumoralMiceMice, Inbred BALB CSalmonella typhimuriumShiga Toxin 2SwineT-LymphocytesVaccines, SyntheticCytokinesEscherichia coli VaccinesShiga Toxin 2Vaccines, SyntheticBacterial ghostEdema diseaseSalmonella typhimuriumShiga toxin

Identifiers

PMID28143511
PMCPMC5286835
OpenAlexW2583234441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.