ArticleJournal of neuroinflammation2017
Obesity and neuroinflammatory phenotype in mice lacking endothelial megalin.
Article in Journal of neuroinflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
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- Progranulin Deficiency Induces Mitochondrial Dysfunction in Frontotemporal Lobar Degeneration with TDP-43 Inclusions.Antioxidants (Basel, Switzerland) · 2023Article
- Chromosome-Level Genome Assembly of the Butter Clam Saxidomus purpuratus.Genome biology and evolution · 2022Article
- The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Review
- Obesity as a Risk Factor for Dementia and Alzheimer's Disease: The Role of Leptin.International journal of molecular sciences · 2022Review
- Scavenger receptors in host defense: from functional aspects to mode of action.Cell communication and signaling : CCS · 2022Review
- Role of adipocyte Na,K-ATPase oxidant amplification loop in cognitive decline and neurodegeneration.iScience · 2021Article
- Is LRP2 Involved in Leptin Transport over the Blood-Brain Barrier and Development of Obesity?International journal of molecular sciences · 2021Article
- Structural Brain Changes Associated with Overweight and Obesity.Journal of obesity · 2021Review
- Endothelial-specific deficiency of megalin in the brain protects mice against high-fat diet challenge.Journal of neuroinflammation · 2020Article
- Neuronal megalin mediates synaptic plasticity-a novel mechanism underlying intellectual disabilities in megalin gene pathologies.Brain communications · 2020Article
- Hypothalamic redox balance and leptin signaling - Emerging role of selenoproteins.Free radical biology & medicine · 2018Review
- The LepR-mediated leptin transport across brain barriers controls food reward.Molecular metabolism · 2018Article
- The Role of Leptin and Adiponectin in Obesity-Associated Cognitive Decline and Alzheimer's Disease.Frontiers in neuroscience · 2018Review
- A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe multiligand receptor megalin controls the brain uptake of a number of ligands, including insulin and leptin. Despite the role of megalin in the transport of these metabolically relevant hormones, the role of megalin at the blood-brain-barrier (BBB) has not yet been explored in the context of metabolic regulation.
methodsHere we investigate the role of brain endothelial megalin in energy metabolism and leptin signaling using an endothelial cell-specific megalin deficient (EMD) mouse model.
resultsWe found megalin is important to protect mice from developing obesity and metabolic syndrome when mice are fed a normal chow diet. EMD mice developed neuroinflammation, by triggering several pro-inflammatory cytokines, displayed reduced neurogenesis and mitochondrial deregulation.
conclusionsThese results implicate brain endothelial megalin expression in obesity-related metabolic changes through the leptin signaling pathway proposing a potential link between obesity and neurodegeneration.
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