ArticleRespiratory research2017
High throughput 16SrRNA gene sequencing reveals the correlation between Propionibacterium acnes and sarcoidosis.
Article in Respiratory research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Exploring microbial signatures in sarcoidosis: etiological and therapeutic implications of host-microbiota interactions.Frontiers in immunology · 2026Review
- Oral microbiome dysbiosis may be associated with intra cranial aneurysms.BMC oral health · 2024Article
- Effect ofFrontiers in veterinary science · 2024Article
- Xpert MTB/RIF assay for the differential diagnosis between sarcoidosis and tuberculosis intrathoracic lymphadenopathy.BMC infectious diseases · 2023Article
- Sarcoidosis rates in BCG-vaccinated and unvaccinated young adults: A natural experiment using Danish registers.Seminars in arthritis and rheumatism · 2023Article
- Immunohistochemical Detection of Potential Microbial Antigens in Granulomas in the Diagnosis of Sarcoidosis.Journal of clinical medicine · 2021Review
- Comparison and Analysis of Gut Microbiota in Children With IgA Vasculitis With Different Clinical Symptoms.Frontiers in pediatrics · 2021Article
- Presence ofERJ open research · 2021Article
- Review
- Toll-like receptors 2 expression in mediastinal lymph node of patients with sarcoidosis.Annals of translational medicine · 2020Article
- Comparison of lung microbiota between antineutrophil cytoplasmic antibody-associated vasculitis and sarcoidosis.Scientific reports · 2020Article
- Serum IL-35 Levels Are Associated With Activity and Progression of Sarcoidosis.Frontiers in immunology · 2020Article
- A review of microscopy-based evidence for the association of Propionibacterium acnes biofilms in degenerative disc disease and other diseased human tissue.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2019Review
- IL-17A Can PromoteFrontiers in immunology · 2019Article
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to use high throughput 16SrRNA gene sequencing to examine the bacterial profile of lymph node biopsy samples of patients with sarcoidosis and to further verify the association between Propionibacterium acnes (P. acnes) and sarcoidosis.
methodsA total of 36 mediastinal lymph node biopsy specimens were collected from 17 cases of sarcoidosis, 8 tuberculosis (TB group), and 11 non-infectious lung diseases (control group). The V4 region of the bacterial 16SrRNA gene in the specimens was amplified and sequenced using the high throughput sequencing platform MiSeq, and bacterial profile was established. The data analysis software QIIME and Metastats were used to compare bacterial relative abundance in the three patient groups.
resultsOverall, 545 genera were identified; 38 showed significantly lower and 29 had significantly higher relative abundance in the sarcoidosis group than in the TB and control groups (P < 0.01). P. acnes 16SrRNA was exclusively found in all the 17 samples of the sarcoidosis group, whereas was not detected in the TB and control groups. The relative abundance of P. acnes in the sarcoidosis group (0.16% ± 0. 11%) was significantly higher than that in the TB (Metastats analysis: P = 0.0010, q = 0.0044) and control groups (Metastats analysis: P = 0.0010, q = 0.0038). The relative abundance of P. granulosum was only 0.0022% ± 0. 0044% in the sarcoidosis group. P. granulosum 16SrRNA was not detected in the other two groups.
conclusionHigh throughput 16SrRNA gene sequencing appears to be a useful tool to investigate the bacterial profile of sarcoidosis specimens. The results suggest that P. acnes may be involved in sarcoidosis development.
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