ArticleBMC complementary and alternative medicine2017
Anti-inflammatory potential of Capparis spinosa L. in vivo in mice through inhibition of cell infiltration and cytokine gene expression.
Article in BMC complementary and alternative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Extracellular Vesicles fromNanomaterials (Basel, Switzerland) · 2026Article
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- Dietary modulation shapes gut microbiota and digestive physiology associated with specialized frugivory inFrontiers in microbiology · 2025Article
- Sedative and anxiolytic effects ofFrontiers in pharmacology · 2024Article
- The Current State of Knowledge about the Biological Activity of Different Parts of Capers.Nutrients · 2023Review
- Dietary phytochemical and metabolic disease prevention: Focus on plant proteins.Frontiers in nutrition · 2023Review
- Quality variation and biosynthesis of anti-inflammatory compounds forFrontiers in plant science · 2023Article
- Effects of Capparis Spinosa extract on the neuropathic pain induced by chronic constriction injury in rats.Metabolic brain disease · 2022Article
- Ketogenic and Modified Mediterranean Diet as a Tool to Counteract Neuroinflammation in Multiple Sclerosis: Nutritional Suggestions.Nutrients · 2022Review
- In vitro efficacy of Capparis spinosa extraction against larvae viability of Echinococcus granulosus sensu stricto.The Journal of veterinary medical science · 2022Article
- Caper (Frontiers in pharmacology · 2022Review
- The Fading Wild Plant Food-Medicines in Upper Chitral, NW Pakistan.Foods (Basel, Switzerland) · 2021Article
- Anti-Inflammatory Activity of a Medicinal Herb Extract Mixture, HM-V, on an Animal Model of DNCB-Induced Chronic Skin Inflammation.Plants (Basel, Switzerland) · 2021Article
- Article
- Daily Consumption of Caper Fruit Along With Atorvastatin Has Synergistic Effects in Hyperlipidemic Patients: Randomized Clinical Trial.Galen medical journal · 2019Article
- Phytochemical and Pharmacological Properties of Capparis spinosa as a Medicinal Plant.Nutrients · 2018Review
- Effect of Daily Caper Fruit Pickle Consumption on Disease Regression in Patients with Non-Alcoholic Fatty Liver Disease: a Double-Blinded Randomized Clinical Trial.Advanced pharmaceutical bulletin · 2017Article
- Review
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10 authors.
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Abstract
backgroundSeveral chronic inflammatory diseases are characterized by inappropriate CD4+ T cell response. In the present study, we assessed the ability of Capparis spinosa L. (CS) preparation to orientate, in vivo, the immune response mediated by CD4+ T cells towards an anti-inflammatory response.
methodsThe in vivo study was carried out by using the contact hypersensitivity (CHS) model in Swiss mice. Then we performed a histological analysis followed by molecular study by using real time RT-PCR. We also realized a phytochemical screening and a liquid-liquid separation of CS preparation.
resultsOur study allowed us to detect a significantly reduced edema in mice treated with CS preparations relative to control. CS effect was dose dependent, statistically similar to that observed with indomethacin, independent of the plant genotype and of the period of treatment. Furthermore, our histology studies revealed that CS induced a significant decrease in immune cell infiltration, in vasodilatation and in dermis thickness in the inflammatory site. Interestingly, we showed that CS operated by inhibiting cytokine gene expression including IFNγ, IL-17 and IL-4. Besides, phytochemical screening of CS extract showed the presence of several chemical families such as saponins, flavonoids and alkaloids. One (hexane fraction) out of the three distinct prepared fractions, exhibited an anti-inflammatory effect similar to that of the raw preparation, and would likely contain the bioactive(s) molecule(s).
conclusionsAltogether, our data indicate that CS regulates inflammation induced in vivo in mice and thus could be a source of anti-inflammatory molecules, which could be used in some T lymphocyte-dependent inflammatory diseases.
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