ArticleBMC psychiatry2017
Brain structural and functional dissociated patterns in schizophrenia.
Article in BMC psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Altered brain functional networks in schizophrenia with persistent negative symptoms: an activation likelihood estimation meta-analysis.Frontiers in human neuroscience · 2023Pooled it
- Meta-analysis of structural and functional brain abnormalities in schizophrenia with persistent negative symptoms using activation likelihood estimation.Frontiers in psychiatry · 2022Pooled it
- Noninvasive Mapping of Striosome-Matrix Imbalance in Early Psychosis.Biological psychiatry global open science · 2026Article
- Network localization of genetic risk for schizophrenia and bipolar disorder.Psychological medicine · 2025Article
- Mapping individualized multi-scale hierarchical brain functional networks from fMRI by self-supervised deep learning.bioRxiv : the preprint server for biology · 2025Article
- A comparative machine learning study of schizophrenia biomarkers derived from functional connectivity.Scientific reports · 2025Article
- Altered cortical thickness associated with psychotic symptoms and cognitive profiles in involuntarily hospitalized, first-episode, drug-naive patients with schizophrenia.Frontiers in psychiatry · 2025Article
- Functional Connectivity Biomarker Extraction for Schizophrenia Based on Energy Landscape Machine Learning Techniques.Sensors (Basel, Switzerland) · 2024Article
- Transcriptional signatures of the whole-brain voxel-wise resting-state functional network centrality alterations in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Dysconnection and cognition in schizophrenia: A spectral dynamic causal modeling study.Human brain mapping · 2023Article
- Computing personalized brain functional networks from fMRI using self-supervised deep learning.Medical image analysis · 2023Article
- Progressive brain abnormalities in schizophrenia across different illness periods: a structural and functional MRI study.Schizophrenia (Heidelberg, Germany) · 2023Article
- Longer illness duration is associated with greater individual variability in functional brain activity in Schizophrenia, but not bipolar disorder.NeuroImage. Clinical · 2022Article
- Transcranial direct current stimulation of the occipital lobes with adjunct lithium attenuates the progression of cognitive impairment in patients with first episode schizophrenia.Frontiers in psychiatry · 2022Article
- Regularized Functional Connectivity in Schizophrenia.Frontiers in human neuroscience · 2022Article
- Unstructured Group Support Enhances Compliance to Pharmacological Treatment by Improving Social Cognition in Patients with Bipolar Disorder: A Pilot fMRI Study.Psychiatry and clinical psychopharmacology · 2021Article
- Pharmaco-Magnetic Resonance as a Tool for Monitoring the Medication-Related Effects in the Brain May Provide Potential Biomarkers for Psychotic Disorders.International journal of molecular sciences · 2021Review
- Spatial Stability of Functional Networks: A Measure to Assess the Robustness of Graph-Theoretical Metrics to Spatial Errors Related to Brain Parcellation.Frontiers in neuroscience · 2021Article
- COMT-Val158Met polymorphism modulates antipsychotic effects on auditory verbal hallucinations and temporal lobe gray matter volumes in healthy individuals-symptom relief accompanied by worrisome volume reductions.Brain imaging and behavior · 2020Article
- Exploring concomitant neuroimaging and genetic alterations in patients with and patients without auditory verbal hallucinations: A pilot study and mini review.The Journal of international medical research · 2020Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough previous studies found that aberrations in gray matter volume (GMV) and global functional connectivity density (gFCD) are important characteristics of schizophrenia, to the best of our knowledge no study to date has investigated the associations between the spatial distribution patterns of GMV and gFCD alterations. We investigated pattern changes in gFCD and GMV among patients with schizophrenia and their associated spatial distributions.
methodsNinety-five patients with schizophrenia and 93 matched healthy controls underwent structural and resting-state functional MRI scanning to assess gFCD and GMV.
resultsWe found that gFCD increased in the subcortical regions (caudate, pallidum, putamen, and thalami) and limbic system (left hippocampus and parahippocampus), and decreased in the posterior parieto-occipito-temporal cortices (postcentral gyri, occipital cortex, temporo-occipital conjunction, and inferior parietal lobule), in patients with schizophrenia. By contrast, we found decreased GMV in brain regions including the frontal, parietal, temporal, occipital, cingulate cortices, and the insular, striatum, thalamus in these patients. Increased gFCD primarily occurred in subcortical regions including the basal ganglia and some regions of the limbic system. Decreased gFCD appeared primarily in the cortical regions. There were no statistically significant correlations between changes in gFCD and GMV, and their spatial distribution patterns, in different regions.
conclusionsOur findings indicate that gFCD and GMV are both perturbed in multiple brain regions in schizophrenia. gFCD and GMV consistently decreased in the cortical regions, with the exception of the Supplementary Motor Area (SMA). However, in the sub-cortical regions, the alterations of gFCD and GMV showed the opposite pattern, with increased gFCD and decreased GMV simultaneously observed in these regions. Overall, our findings suggest that structural and functional alterations appear to contribute independently to the neurobiology of schizophrenia.
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