ArticleBMC infectious diseases2017
The immunological response to syphilis differs by HIV status; a prospective observational cohort study.
Article in BMC infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Independent clinic-based evaluation of dual POCTs for screening for HIV and syphilis in men who have sex with men in Italy, Malta, Peru, and the United Kingdom.BMC infectious diseases · 2024Pooled it
- IL-10 and IL-17 as Progression Markers of Syphilis in People Living with HIV: A Systematic Review.Biomolecules · 2022Pooled it
- Serum Cytokines and TGF-β1: A Window into Syphilis Among People Living with HIV.Pathogens (Basel, Switzerland) · 2026Article
- Time-course transcriptomics reveals the impact ofFrontiers in microbiology · 2025Article
- Increased HIV and other sexually transmitted infections in two health facilities in Northern Cameroon between 2021 and 2022.Journal of public health in Africa · 2025Article
- The Significance of the Cell-Mediated Host Immune Response in Syphilis.Microorganisms · 2024Review
- Article
- Leukocytoclastic vasculitis in a patient with syphilis and HIV coinfection.Revista do Instituto de Medicina Tropical de Sao Paulo · 2022Article
- Alterations of CCR2 and CX3CR1 on Three Monocyte Subsets During HIV-1/Frontiers in medicine · 2020Article
- Cytokine expression in Treponema pallidum infection.Journal of translational medicine · 2019Article
- Syphilis reinfection is associated with an attenuated immune profile in the same individual: a prospective observational cohort study.BMC infectious diseases · 2018Article
- Repeat Syphilis Is More Likely to Be Asymptomatic in HIV-Infected Individuals: A Retrospective Cohort Analysis With Important Implications for Screening.Open forum infectious diseases · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is not known if there is a difference in the immune response to syphilis between HIV-infected and uninfected individuals.
methodsWe prospectively recruited all patients with a new diagnosis of syphilis and tested their plasma for IFNα, IFNγ, IL-1β, IL-12p40, IL-12p70, IP-10, MCP-1, MIP-1α, MIP-1β, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10 and IL-17A at baseline pre-treatment and 6 months following therapy.
resultsA total of 79 HIV-infected [44 primary/secondary syphilis (PSS) and 35 latent syphilis (LS)] and 12 HIV-uninfected (10 PSS and 2 LS) cases of syphilis and 30 HIV-infected controls were included in the study. At the baseline visit, compared to the control group, concentrations of IL-10 were significantly elevated in the HIV-infected and uninfected groups. The level of IL-10 was significantly higher in the HIV-infected compared to the HIV-uninfected PSS group (25.3 pg/mL (IQR, 4.56-41.76) vs 2.73 pg/mL (IQR, 1.55-9.02), P = 0.0192). In the HIV-infected PSS group (but not the HIV-infected LS or HIV-uninfected PSS groups) the IP-10, MIP-1b, IL-6 and IL-8 were raised compared to the controls. IL-10 levels decreased but did not return to control baseline values by 6 months in HIV infected PSS and LS and HIV uninfected PSS.
conclusionPSS and LS in HIV-infected individuals is characterized by an increase in inflammatory and anti-inflammatory cytokines such as IL-10. The increase of IL-10 is greater in HIV-infected than uninfected individuals. Further work is required to ascertain if this is part of an immunological profile that correlates with adverse outcomes such as serofast syphilis and neurosyphilis, in HIV-infected individuals.
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