Observational studyBMC cancer2017
Mammographic breast density and risk of breast cancer in women with atypical hyperplasia: an observational cohort study from the Mayo Clinic Benign Breast Disease (BBD) cohort.
Observational study in BMC cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Associations of local breast density with patient characteristics and risk of breast cancer among women undergoing diagnostic breast biopsy.Breast cancer research : BCR · 2026Article
- Mechanisms of osteopontin-stabilized amorphous calcium phosphate calcification in benign and pre-malignant breast disease.Scientific reports · 2025Article
- Polygenic risk scores stratify breast cancer risk among women with benign breast disease.Journal of the National Cancer Institute · 2025Article
- A systematic review of determinants of breast cancer risk among women with benign breast disease.NPJ breast cancer · 2025Article
- Relationship between breast tissue involution and breast cancer.Frontiers in oncology · 2025Review
- Long term follow-up of women treated for screen detected atypical ductal hyperplasia or lobular neoplasia in a large UK screening centre.BJC reports · 2024Article
- Body mass index, breast density, and the risk of breast cancer development in relation to the menopausal status; results from a population-based screening program in a native African-Arab country.Acta radiologica open · 2022Article
- The impact of mammographic screening on the subsequent breast cancer risk associated with biopsy-proven benign breast disease.NPJ breast cancer · 2021Article
- Density of breast: An independent risk factor for developing breast cancer, a prospective study at two premium breast centers.Cancer medicine · 2020Article
- The Influence of Age on the Histopathology and Prognosis of Atypical Breast Lesions.The Journal of surgical research · 2019Article
- Use of ultrasound combined with magnetic resonance imaging for diagnosis of breast masses and fibroids.The Journal of international medical research · 2019Article
- Epidemiological characteristics of and risk factors for breast cancer in the world.Breast cancer (Dove Medical Press) · 2019Review
- Model for Predicting Breast Cancer Risk in Women With Atypical Hyperplasia.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018Article
- Atypical ductal hyperplasia: update on diagnosis, management, and molecular landscape.Breast cancer research : BCR · 2018Review
- Breast Cancer Prevention: Current Approaches and Future Directions.European journal of breast health · 2018Review
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAtypical hyperplasia (AH) and mammographic breast density (MBD) are established risk factors for breast cancer (BC), but their joint contributions are not well understood. We examine associations of MBD and BC by histologic impression, including AH, in a subcohort of women from the Mayo Clinic Benign Breast Disease Cohort.
methodsWomen with a diagnosis of BBD and mammogram between 1985 and 2001 were eligible. Histologic impression was assessed via pathology review and coded as non-proliferative disease (NP), proliferative disease without atypia (PDWA) and AH. MBD was assessed clinically using parenchymal pattern (PP) or BI-RADS criteria and categorized as low, moderate or high. Percent density (PD) was also available for a subset of women. BC and clinical information were obtained by questionnaires, medical records and the Mayo Clinic Tumor Registry. Women were followed from date of benign biopsy to BC, death or last contact. Standardized incidence ratios (SIRs) compared the observed number of BCs to expected counts. Cox regression estimated multivariate-adjusted MBD hazard ratios.
resultsOf the 6271 women included in the study, 1132 (18.0%) had low MBD, 2921 (46.6%) had moderate MBD, and 2218 (35.4%) had high MBD. A total of 3532 women (56.3%) had NP, 2269 (36.2%) had PDWA and 470 (7.5%) had AH. Over a median follow-up of 14.3 years, 528 BCs were observed. The association of MBD and BC risk differed by histologic impression (p-interaction = 0.03), such that there was a strong MBD and BC association among NP (p < 0.001) but non-significant associations for PDWA (p = 0.27) and AH (p = 0.96). MBD and BC associations for AH women were not significant within subsets defined by type of MBD measure (PP vs. BI-RADS), age at biopsy, number of foci of AH, type of AH (lobular vs. ductal) and body mass index, and after adjustment for potential confounding variables. Women with atypia who also had high PD (>50%) demonstrated marginal evidence of increased BC risk (SIR 4.98), but results were not statistically significant.
conclusionWe found no evidence of an association between MBD and subsequent BC risk in women with AH.
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