ArticlePharmaceutical biology2017
Effects of Aphloia theiformis on key enzymes related to diabetes mellitus.
Article in Pharmaceutical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 31 citations in OpenAlex.
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- LC-MS/MS Profiles and In Vitro Biological Activities of Extracts of an Endemic Species from Turkey:Plants (Basel, Switzerland) · 2021Article
- UHPLC-DAD Characterization ofMolecules (Basel, Switzerland) · 2021Article
- Mangiferin Rich Products fromMolecules (Basel, Switzerland) · 2020Article
- HPLC-PDA Polyphenolic Quantification, UHPLC-MS Secondary Metabolite Composition, and In Vitro Enzyme Inhibition Potential ofPlants (Basel, Switzerland) · 2020Article
- Article
- GC-MS Analysis and Inhibitory Evaluation ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Extract from Aphloia theiformis, an edible indigenous plant from Reunion Island, impairs Zika virus attachment to the host cell surface.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextAphloia theiformis (Vahl.) Benn. (Flacourtiaceae) (AT) is traditionally used for the management of diabetes mellitus (DM), but there is no scientific data regarding activity against enzymes linked to this condition.
objectiveTo evaluate the kinetics of AT on key enzymes inhibition related to DM, and establish the antioxidant profile of AT. MATERIALS AND
methodsDried powdered AT leaves were used to prepare crude methanol extract (70% v/v) (CME). Kinetics of CME (5000 to 156.25 μg/mL) on α-amylase, α-glucosidase, and lipase inhibition were studied. CME was partitioned using solvents of increasing polarity and kinetics of enzyme inhibition of each fraction (1000-31.25 μg/mL) was evaluated. Potent fractions were combined to assess any synergistic effect. Total phenol, flavonoid, tannin, anthocyanin contents, and antioxidant capacity of AT was evaluated using standard spectrophotometric methods.
resultsCME, ethyl acetate, and n-butanol fractions showed potent inhibitory activities against the enzymes with IC
conclusionThis study supports the use of AT in the management of DM and provides the rationale for bioactivity guided isolation and characterization of compounds from the ethyl acetate and n-butanol fractions.
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