Evidence map›Paper›PMID 28142056›Full record

ArticlePsychiatry research. Neuroimaging2017

Using probabilistic tractography to target the subcallosal cingulate cortex in patients with treatment resistant depression.

Evangelia Tsolaki, Randall Espinoza, Nader Pouratian

Abstract read
In one paragraph

Article in Psychiatry research. Neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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  4. A review of diffusion MRI in mood disorders: mechanisms and predictors of treatment response.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Evangelia TsolakiDepartment of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Electronic address: ETsolaki@mednet.ucla.edu.
Randall EspinozaDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Electronic address: REspinoza@mednet.ucla.edu.
Nader PouratianDepartment of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Electronic address: NPouratian@mednet.ucla.edu.

Funding

Electrophysiologic and Anatomic Basis of BOLD fMRIK23EB014326 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI POURATIAN, NADER · 2012 to 2016
$946k
NIBIB NIH HHS K23 EB014326
6 · The paper itself

Abstract

The lack of efficacy of deep brain stimulation (DBS) of subcallosal cingulate (SCC) in treatment resistant depression (TRD) may be due in part to suboptimal targeting. In two patients treated with SCC DBS for TRD we assessed the voxel-wise probabilistic connectivity of SCC with four tractography-defined target areas implicated in depression, thereby identifying the tractography-optimized target (TOT). Compared to the non-responder, the responder's DBS leads were implanted and stimulation was delivered closer to the TOT. This automated patient-specific data-driven approach provides tomographic maps that could guide DBS targeting and programming with possible implications for improving response to DBS.

Indexed as

AdultDeep Brain StimulationDepressive Disorder, Treatment-ResistantFemaleGyrus CinguliHumansMagnetic Resonance ImagingMaleDeep brain stimulationDepressionProbabilistic tractography

Identifiers

PMID28142056
PMCPMC5552295

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.