Evidence map›Paper›PMID 28141825›Full record

ArticlePloS one2017

Using Triplet Ordering Preferences for Estimating Causal Effects in the Analysis of Gene Expression Data.

Alexander K Hartmann, Grégory Nuel

Abstract read
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alexander K HartmannInstitut für Physik, Universität Oldenburg, 26111 Oldenburg, Germany.ORCID http://orcid.org/0000-0001-6865-5474
Grégory NuelLPMA, CNRS 7599, Université Pierre et Marie Curie, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triplet ordering preferences are used to perform Monte Carlo sampling of the posterior causal orderings originating from the analysis of gene-expression experiments involving observation as well as, usually few, interventions, like knock-outs. The performance of this sampling approach is compared to a previously used sampling via pairwise ordering preference as well as to the sampling of the full posterior distribution. For a fair comparison, the latter approach is restricted to twice the numerical effort of the triplet-based approach. This is done for artificially generated causal, i.e., directed acyclic graphs (DAGs) and for actual experimental data taken from the ROSETTA challenge. The sampling using the triplets ordering turns out to be superior to both other approaches.

Indexed as

AlgorithmsGene ExpressionArea Under CurveDatabases, GeneticLikelihood FunctionsModels, GeneticMonte Carlo MethodROC Curve

Identifiers

PMID28141825
PMCPMC5283676

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.