Evidence map›Paper›PMID 28140742›Full record

ArticleOphthalmic genetics

Cystoid macular changes on optical coherence tomography in a patient with maternally inherited diabetes and deafness (MIDD)-associated macular dystrophy.

Cynthia X Qian, Kari Branham, Naheed Khan, Steven K Lundy, John R Heckenlively, Thiran Jayasundera

Abstract readCase Reports
In one paragraph

Article in Ophthalmic genetics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Fixation behavior in macular dystrophy assessed by microperimetry.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Cynthia X Qiana Kellogg Eye Center , University of Michigan , Ann Arbor , Michigan , USA.
Kari Branhama Kellogg Eye Center , University of Michigan , Ann Arbor , Michigan , USA.
Naheed Khana Kellogg Eye Center , University of Michigan , Ann Arbor , Michigan , USA.
Steven K Lundya Kellogg Eye Center , University of Michigan , Ann Arbor , Michigan , USA.
John R Heckenlivelya Kellogg Eye Center , University of Michigan , Ann Arbor , Michigan , USA.
Thiran Jayasunderaa Kellogg Eye Center , University of Michigan , Ann Arbor , Michigan , USA.
University of Michigan–Ann Arbor · USW.K. Kellogg Foundation · US

Funding

VIVARIUM MODULEP30EY007003 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Antonetti · 1987 to 2026
$17.6M
Targeted functional testing for retinal diseases based on patient reported outcomesK23EY026985 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JAYASUNDERA, KANISHKA THIRAN · 2016 to 2020
$1.2M
NEI NIH HHS K23 EY026985NEI NIH HHS P30 EY007003
6 · The paper itself

Abstract

The clinical presentation and optical coherence tomography findings in a patient with maternally inherited diabetes and deafness (MIDD) are presented to highlight the presence of macular cystoid spaces in some patients with this disease. Typically, patients with MIDD demonstrate progression of a pigmentary maculopathy into areas of geographic macular atrophy. At the time of initial visit, the 30-year-old patient had large macular cystoid changes in addition to retinal pigmentary changes in both eyes. The cystoid changes responded to treatment with systemic immunosuppression and a topical carbonic anhydrase inhibitor (CAI), recurred when treated with topical CAI monotherapy, and finally resolved after an intravitreal triamcinolone acetonide injection. Over time, the retinal atrophy continued to progress, but the macular cysts did not recur. The patient received systemic immunosuppression for renal transplantation due to renal failure resulting from focal glomerulosclerosis. There was no evidence of diabetic retinopathy at any time during the five-and-a-half-year follow-up, and the patient retained good visual acuity in both eyes.

Indexed as

AdultCarbonic Anhydrase InhibitorsDeafnessDiabetes Mellitus, Type 2DNA, MitochondrialElectroretinographyFemaleHumansImmunosuppressive AgentsMacular DegenerationMacular EdemaMitochondrial DiseasesPoint MutationRetinal Pigment EpitheliumSulfonamidesThiophenesCarbonic Anhydrase InhibitorsDNA, MitochondrialdorzolamideImmunosuppressive AgentsSulfonamidesThiophenesCystoid macular changesMIDDmitochondrial mutationpigmentary macular dystrophy

Identifiers

PMID28140742
PMCPMC5568973
OpenAlexW2583381238

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.