ArticleJournal of natural products2017
Probing Labdane-Related Diterpenoid Biosynthesis in the Fungal Genus Aspergillus.
Article in Journal of natural products, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Discovery of a dimeric isopimarane derivative by reexploring a labdane-related diterpenoid biosynthetic gene cluster in Aspergillus nidulans.Microbial cell factories · 2026Article
- A Chlorine-Bearing Asymmetric Center as a Stereocontrol Element in a Short Formal Synthesis of Steviol.Synthesis · 2025Article
- Genomic analysis of terpene synthase family and characterization of ent-kaurene synthase in Chenopodium quinoa.Molecular genetics and genomics : MGG · 2025Article
- Genome mining of labdane-related diterpenoids: Discovery of the two-enzyme pathway leading to (-)-sandaracopimaradiene in the fungusBeilstein journal of organic chemistry · 2024Article
- Origin and early evolution of the plant terpene synthase family.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Diterpene Biosynthesis in Rice Blast FungusFrontiers in fungal biology · 2022Article
- Functional characterization and structural bases of two class I diterpene synthases in pimarane-type diterpene biosynthesis.Communications chemistry · 2021Article
- Trinorlabdane diterpenoid alkaloids featuring an unprecedented skeleton with anti-inflammatory and anti-viral activities fromRSC advances · 2021Article
- Identification of Three Monofunctional Diterpene Synthases with Specific Enzyme Activities Expressed during Heartwood Formation in Western Redcedar (Plants (Basel, Switzerland) · 2020Article
- Sarcosenones A-C, highly oxygenated pimarane diterpenoids from an endolichenic fungusRSC advances · 2020Article
- Recent Advances inNutrients · 2019Review
- Premutilin Synthase: Ring Rearrangement by a Class II Diterpene Cyclase.Organic letters · 2018Article
- Structural and Chemical Biology of Terpenoid Cyclases.Chemical reviews · 2017Review
- Biosynthesis of the oxygenated diterpene nezukol in the medicinal plant Isodon rubescens is catalyzed by a pair of diterpene synthases.PloS one · 2017Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
While terpenoid production is generally associated with plants, a variety of fungi contain operons predicted to lead to such biosynthesis. Notably, fungi contain a number of cyclases characteristic of labdane-related diterpenoid metabolism, which have not been much explored. These also are often found near cytochrome P450 (CYP) mono-oxygenases that presumably further decorate the ensuing diterpene, suggesting that these fungi might produce more elaborate diterpenoids. To probe the functional diversity of such biosynthetic capacity, an investigation of the phylogenetically diverse cyclases and associated CYPs from the fungal genus Aspergillus was undertaken, revealing their ability to produce isopimaradiene-derived diterpenoids. Intriguingly, labdane-related diterpenoid biosynthetic genes are largely found in plant-associated fungi, hinting that these natural products may play a role in such interactions. Accordingly, it is hypothesized here that isopimarane production may assist the plant-saprophytic lifestyle of Aspergillus fungi.
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