Evidence map›Paper›PMID 28140471›Full record

ArticlePaediatric and perinatal epidemiology2017

Use of Intracytoplasmic Sperm Injection and Birth Outcomes in Women Conceiving through In Vitro Fertilization.

Xu Xiong, Richard P Dickey, Pierre Buekens, Jeffrey G Shaffer, Gabriella Pridjian

Abstract read
PubMed Publisher
In one paragraph

Article in Paediatric and perinatal epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. IVF or ICSI for fertility preservation?Reproduction & fertility · 2021
    Article
  5. The risk of birth defects with conception by ART.Human reproduction (Oxford, England) · 2021
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xu XiongDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA.ORCID 0000-0001-9292-5059
Richard P DickeySection of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Louisiana State University School of Medicine, and The Fertility Institute of New Orleans, Mandeville, LA.
Pierre BuekensDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA.
Jeffrey G ShafferDepartment of Biostatistics and Bioinformatics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA.
Gabriella PridjianDepartment of Obstetrics and Gynecology, Tulane University School of Medicine, New Orleans, LA.
Tulane University · USLouisiana State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite questionable evidence of benefits over conventional in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI) use has markedly increased in recent decades among couples without male factor infertility. We assessed the frequency of ICSI use and its effect on birth outcomes.

methodsA retrospective cohort study was conducted in 141 030 women conceiving through IVF using 2006-2010 data from the Society for Assisted Reproductive Technology (SART).

resultsBetween 2006 and 2010, overall ICSI use in women conceiving through IVF increased from 68.9% to 73.1%. This increase was greater among women without male factor infertility (53.0-59.2%) than in women with male factor infertility (92.0-93.4%). Women conceiving through IVF with and without ICSI had similar rates of multiple pregnancy, preterm delivery, stillbirth, and neonatal death. However, ICSI pregnancies were associated with an increased risk of birth defects over conventional IVF (3.0% for ICSI vs. 2.5% for conventional IVF; adjusted odds ratio (OR) 1.2, 95% confidence interval (CI) 1.2, 1.3). These increases were observed in both women conceiving through ICSI with male factor infertility (3.2% vs. 2.5%; OR 1.4, 95% CI 1.3, 1.5) and without male factor infertility (2.7% vs. 2.5%; OR 1.1, 95% CI 1.1, 1.2).

conclusionsHigher rates of birth defects were observed among women conceiving through ICSI. Since approximately half of all ICSI procedures are performed in couples without male factor infertility, ICSI may be overused in practice.

Indexed as

AdultFemaleHumansInfertility, MaleMaleMiddle AgedPregnancyPregnancy, MultiplePregnancy OutcomePregnancy RateRetrospective StudiesRisk FactorsSperm Injections, Intracytoplasmicbirth defectsinfertilityintracytoplasmic sperm injectionin vitro fertilizationpregnancy

Identifiers

PMID28140471
OpenAlexW2585242747

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.