ArticleTranslational psychiatry2017
Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models.
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Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 215 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
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215citing papers in PubMed, 8 pooled it
22.5field-weighted citation impact, top 1% of its field
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Who cites it
215 citing papers in PubMed, 8 syntheses or guidelines pooled it, 425 citations in OpenAlex.
- The association between air pollution and cognitive impairment: a systematic review and meta- analysis of global studies.BMC public health · 2025Pooled it
- Beneficial Effect of Societal Factors on APOE-ε2 and ε4 Carriers' Brain Health: A Systematic Review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Pooled it
- Ambient air pollution and clinical dementia: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2023Pooled it
- Air Pollution and Cognitive Impairment across the Life Course in Humans: A Systematic Review with Specific Focus on Income Level of Study Area.International journal of environmental research and public health · 2022Pooled it
- Exposure to Air Pollution in Relation to Risk of Dementia and Related Outcomes: An Updated Systematic Review of the Epidemiological Literature.Environmental health perspectives · 2021Pooled it
- Characteristics of cohort studies of long-term exposure to PMEnvironmental science and pollution research international · 2019Pooled it
- Air Pollution and Dementia: A Systematic Review.Journal of Alzheimer's disease : JAD · 2019Pooled it
- The genetic association between apolipoprotein E gene polymorphism and Parkinson disease: A meta-Analysis of 47 studies.Medicine · 2018Pooled it
- Randomized Cross-Over Study of In-Vehicle Cabin Air Filtration, Air Pollution Exposure, and Acute Changes to Heart Rate Variability, Saliva Cortisol, and Cognitive Function.Environmental science & technology · 2023Trial
- Environmental Pollution, Biomarkers, and Dementia: An Evidence Review.International journal of molecular sciences · 2026Review
- Advances in Alzheimer's disease: mechanistic insights and therapeutic targets.Science China. Life sciences · 2026Review
- Circular RNAEnvironment & health (Washington, D.C.) · 2026Article
- Acute wood smoke exposure is associated with cell-specific hippocampal transcriptomic responses in an accelerated ovarian failure mouse model.Neurotoxicology · 2026Article
- A critical review of potential modifiers of air pollutant associations with dementia and related outcomes.Neurotoxicology · 2026Review
- Inhibition of EPAC1 Prevents Neuronal Death Mediated by Diesel Exhaust Particles in Ferroptotic Cell Death Conditions.Antioxidants (Basel, Switzerland) · 2026Article
- Associations between air pollution and markers of neuroinflammation, synaptic dysfunction and core Alzheimer's disease pathology vary by APOE genotype.Neurotoxicity research · 2026Article
- Spatial and spectral mapping of traffic-related nanoparticles in hippocampal subregions of an Alzheimer disease model.Environmental pollution (Barking, Essex : 1987) · 2026Article
- The sex-specific association between long-term PM2.5 exposure and incident dementia in community-dwelling older adults in Australia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Can we refute a role for infections in Alzheimer's disease pathogenesis?Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Systems biology of Alzheimer's Disease: a scoping review of key pathways and mechanisms.Molecular neurodegeneration · 2026Article
155 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 1 country.
M CacciottoloLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
X WangDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
I DriscollDepartment of Psychology, University of Wisconsin, Milwaukee, WI, USA.
N WoodwardLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
A SaffariUSC Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
J ReyesDepartment of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
M L SerreDepartment of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
W VizueteDepartment of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
C SioutasUSC Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
T E MorganLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
M GatzDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
H C ChuiMemory and Aging Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
S A ShumakerDepartment of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA.
S M ResnickLaboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
M A EspelandDivision of Public Health Services, Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
C E FinchLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
J C ChenDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
University of Southern California · USUniversity Memory and Aging Center · USUniversity of North Carolina at Chapel Hill · USWake Forest University · USNational Institutes of Health · USUniversity of Wisconsin–Milwaukee · US
Funding
Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Joseph Leo Wiemels · 1996 to 2026
$46.4MVASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARANDA, MARIA P. · 1985 to 2019
$41.0MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3MAlzheimer's Disease & Related Dementias: Geography, Environments, and MechanismsRF1AG054068 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN · 2016 to 2016
$4.1MEnvironmental Determinants of Pathological Brain Aging in WHI Memory StudiesR01ES025888 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN, KAUFMAN, JOEL DANIEL · 2016 to 2020
$3.2MAmyloid and inflammation: modulation by apoE, gender, air pollution, and drugsRF1AG051521 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FINCH, CALEB E · 2015 to 2015
$3.0MEnvironmental Determinants of Cognitive Aging in the WHI Memory StudyR01AG033078 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN · 2011 to 2014
$2.6MWomen's Health Initiative Suite of Studies - Extension StudyZIAAG000190 · NIA · NATIONAL INSTITUTE ON AGING · PI RESNICK, SUSAN · 2009 to 2024
$1.5MThe aging brain: Imaging genetics of brain structure and functionR00AG032361 · NIA · UNIVERSITY OF WISCONSIN MILWAUKEE · PI FRAHMAND, IRA · 2011 to 2013
$719kNeurodevelopment in Urban Environments: Role of Exposure to Ambient Air PollutionR21ES022369 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BAKER, LAURA A, CHEN, JIU-CHIUAN · 2013 to 2014
$468kAir pollution nano-particulate matter, APP processing, and glutamate receptorsR21AG050201 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FINCH, CALEB E · 2016 to 2017
$454kAging and sensitivity to traffic-generated air pollutants in male and female miceR21AG040753 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FINCH, CALEB E · 2011 to 2012
$365kNHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNIA NIH HHS HHSN271201100004CNIA NIH HHS P50 AG005142NIA NIH HHS R00 AG032361NIA NIH HHS R01 AG033078NIA NIH HHS R21 AG040683NIA NIH HHS R21 AG040753NIA NIH HHS R21 AG050201NIA NIH HHS RF1 AG051521NIA NIH HHS RF1 AG054068NIEHS NIH HHS P30 ES007048NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R01 ES025888NIEHS NIH HHS R21 ES022369WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
Abstract
Exposure to particulate matter (PM) in the ambient air and its interactions with APOE alleles may contribute to the acceleration of brain aging and the pathogenesis of Alzheimer's disease (AD). Neurodegenerative effects of particulate air pollutants were examined in a US-wide cohort of older women from the Women's Health Initiative Memory Study (WHIMS) and in experimental mouse models. Residing in places with fine PM exceeding EPA standards increased the risks for global cognitive decline and all-cause dementia respectively by 81 and 92%, with stronger adverse effects in APOE ɛ4/4 carriers. Female EFAD transgenic mice (5xFAD
Indexed as
Gene-Environment InteractionParticulate MatterAgedAlzheimer DiseaseAmyloid beta-PeptidesAnimalsApolipoprotein E4AtrophyCA1 Region, HippocampalCell Line, TumorCerebrumCognitive DysfunctionDementiaEnvironmental ExposureFemaleHumansAmyloid beta-PeptidesApolipoprotein E4Particulate MatterReceptors, AMPA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.