ArticleTranslational psychiatry2017
Further support for association between GWAS variant for positive emotion and reward systems.
Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Interaction of miR-181b andBioMed research international · 2020Trial
- Review
- Reward processes in extinction learning and applications to exposure therapy.Journal of anxiety disorders · 2024Review
- miR-181a targets PTEN to mediate the neuronal injury caused by oxygen-glucose deprivation and reoxygenation.Metabolic brain disease · 2023Article
- Should Reward Deficiency Syndrome (RDS) Be Considered an Umbrella Disorder for Mental Illness and Associated Genetic and Epigenetic Induced Dysregulation of Brain Reward Circuitry?Journal of personalized medicine · 2022Article
- Gene expression associated with human brain activations in facial expression recognition.Brain imaging and behavior · 2022Article
- Developmental trajectories to reduced activation of positive valence systems: A review of biological and environmental contributions.Developmental cognitive neuroscience · 2020Review
- Genomics and psychological resilience: a research agenda.Molecular psychiatry · 2019Review
- Structural and Functional Neuroimaging of Polygenic Risk for Schizophrenia: A Recall-by-Genotype-Based Approach.Schizophrenia bulletin · 2019Article
- Preliminary evidence for genetic overlap between body mass index and striatal reward response.Translational psychiatry · 2018Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
A recent genome-wide association study (GWAS) identified a significant single-nucleotide polymorphism (SNP) for trait-positive emotion at rs322931 on chromosome 1, which was also associated with brain activation in the reward system of healthy individuals when observing positive stimuli in a functional magnetic resonance imaging (fMRI) study. In the current study, we aimed to further validate the role of variation at rs322931 in reward processing. Using a similar fMRI approach, we use two paradigms that elicit a strong ventral striatum (VS) blood oxygen-level dependency (BOLD) response in a sample of young, healthy individuals (N=82). In the first study we use a similar picture-viewing task to the discovery sample (positive>neutral stimuli) to replicate an effect of the variant on emotion processing. In the second study we use a probabilistic reversal learning procedure to identify reward processing during decision-making under uncertainly (reward>punishment). In a region of interest (ROI) analysis of the bilateral VS, we show that the rs322931 genotype was associated with BOLD in the left VS during the positive>neutral contrast (P
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.