SynthesisAdvances in nutrition (Bethesda, Md.)2016
Whole-Grain Intake and Mortality from All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
Synthesis in Advances in nutrition (Bethesda, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Whole Grains, Refined Grains, and Cancer Risk: A Systematic Review of Meta-Analyses of Observational Studies.Nutrients · 2020Pooled it
- Dietary total antioxidant capacity and mortality from all causes, cardiovascular disease and cancer: a systematic review and dose-response meta-analysis of prospective cohort studies.European journal of nutrition · 2019Pooled it
- Mediterranean Diet Pyramid: A Proposal for Italian People. A Systematic Review of Prospective Studies to Derive Serving Sizes.Nutrients · 2019Pooled it
- Pooled it
- Evaluating Mediterranean diet and risk of chronic disease in cohort studies: an umbrella review of meta-analyses.European journal of epidemiology · 2018Pooled it
- Association of whole grain intake with all-cause, cardiovascular, and cancer mortality: a systematic review and dose-response meta-analysis from prospective cohort studies.European journal of clinical nutrition · 2018Pooled it
- Effects of 12-Week Sorghum Consumption on Visceral Fat Area and Metabolic Parameters in Japanese Adults: An Exploratory Single-Arm Trial.Nutrients · 2026Trial
- Comprehensive Two-Dimensional Gas Chromatography-Mass Spectrometry Analysis of Exhaled Breath Compounds after Whole Grain Diets.Molecules (Basel, Switzerland) · 2021Trial
- Elucidation of the Effects of Heat Treatment on Polyphenolic Compounds in Highland Barley and Their Potential Mechanisms of Action in Improving Hypertension Using Targeted Metabolomics, Network Pharmacology, and Molecular Docking.Foods (Basel, Switzerland) · 2026Article
- Socio-Demographic Variation in Adherence to the Eatwell Guide Within the UK Biobank Prospective Cohort Study.Nutrition bulletin · 2026Article
- Knowledge, Perceived Barriers, and Whole-Grain Bread Consumption among University Students in Southwest Iran in the 2024-2025 Academic Year: A Cross-Sectional Study.Health science reports · 2026Article
- The associations of emotion regulation, self-compassion, and perceived lifestyle discrepancy with breast cancer survivors' healthy lifestyle maintenance.Journal of cancer survivorship : research and practice · 2026Article
- Dry-Milled Corn and Corn Products and Health: A Narrative Review.Food science & nutrition · 2026Review
- Adherence to the Provegetarian Food Patterns and Incidence of All-Cause Mortality in a Mediterranean Population: The SUN Cohort.Nutrients · 2025Article
- Should Grain-Based Staple Foods Be Included in Admonitions to "Avoid Processed and Ultra-Processed Food"?Nutrients · 2025Review
- Whole grain intake among young children ages 12 to 48 months participating in the Feeding Infants and Toddlers Study was higher in 2016 compared to 2008.Nutrition research (New York, N.Y.) · 2025Article
- Relationship between staple food types and cardiovascular disease risk among older Chinese adults.Frontiers in nutrition · 2025Article
- Bread Consumption and Cancer Risk: Systematic Review and Meta-Analysis of Prospective Cohort Studies.Current developments in nutrition · 2024Review
- Genetically predicted dietary macronutrient intakes and atrial fibrillation risk: a Mendelian randomization study.European journal of medical research · 2024Article
- The Impact of the COVID-19 Pandemic on Health Behaviours of Pregnant Women in Poland: A Cross-Sectional Study.Nutrients · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
No conclusive information is available about the relation between the consumption of whole grains and the risk of mortality. We aimed to conduct a meta-analysis of prospective cohort studies to summarize the relation between whole-grain intake and risk of mortality from all causes, cardiovascular disease, and total and specific cancers. A systematic search of the literature published earlier than March 2015 was conducted in Medline and PubMed, SCOPUS, EMBASE, and Cochrane Library to identify relevant articles. Prospective cohort studies that examined the association of total whole-grain intake or specific whole-grain foods with risk of mortality from all causes, cardiovascular disease, and total and specific cancers were considered. Twenty prospective cohort studies were included in the systematic review: 9 studies reported total whole-grain intake and 11 others reported specific whole-grain food intake. In a follow-up period of 5.5 to 26 y, there were 191,979 deaths (25,595 from cardiovascular disease, 32,746 from total cancers, and 2671 from specific cancers) in 2,282,603 participants. A greater intake of both total whole grains and specific whole-grain foods was significantly associated with a lower risk of all-cause mortality in the meta-analysis. The pooled RR for all-cause mortality for an increase of 3 servings total whole grains/d (90 g/d) was 0.83 (95% CI: 0.79, 0.88). Total whole-grain intake (0.84; 95% CI: 0.76, 0.93) and specific whole-grain foods (0.82; 95% CI: 0.75, 0.90) were also associated with a reduced risk of mortality from cardiovascular disease. Each additional 3 servings total whole grains/d was associated with a 25% lower risk of mortality from cardiovascular disease. An inverse association was observed between whole-grain intake and risk of mortality from total cancers (0.94; 95% CI: 0.91, 0.98). We found an inverse association between whole-grain intake and mortality from all causes, cardiovascular disease, and total cancers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.