Evidence map›Paper›PMID 28139974›Full record

ArticleeLife2017

The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 α-enhancer activity.

Yeha Kim, Soyeon Lim, Taejeong Ha, You-Hyang Song, Young-In Sohn, Dae-Jin Park, Sun-Sook Paik, Joo-Ri Kim-Kaneyama, Mi-Ryoung Song, Amanda Leung and 6 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Unique activities of two overlappingLife science alliance · 2023
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Signaling Mechanisms of Myofibroblastic Activation: Outside-in and Inside-Out.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2018
    Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Yeha KimDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea.
Soyeon LimDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea.
Taejeong HaDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea.
You-Hyang SongDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea.
Young-In SohnDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea.
Dae-Jin ParkDepartment of Physiology, Chungbuk National University School of Medicine, Cheongju, South Korea.
Sun-Sook PaikDepartment of Anatomy, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Joo-Ri Kim-KaneyamaDepartment of Biochemistry, Showa University School of Medicine, Tokyo, Japan.
Mi-Ryoung SongDepartment of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, South Korea.
Amanda LeungDepartment of Ophthalmology and Visual Sciences, Vanderbilt University, Nashville, United States.
Edward M LevineDepartment of Ophthalmology and Visual Sciences, Vanderbilt University, Nashville, United States.
In-Beom KimDepartment of Anatomy, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Yong Sook GooDepartment of Physiology, Chungbuk National University School of Medicine, Cheongju, South Korea.
Seung-Hee LeeDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea.ORCID 0000-0002-9486-5771
Kyung Hwa KangKAIST Institute of BioCentury, Daejeon, South Korea.
Jin Woo KimDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea.ORCID 0000-0003-0767-1918
Korea Advanced Institute of Science and Technology · KRCatholic University of Korea · KRChungbuk National University · KRVanderbilt University · USGwangju Institute of Science and Technology · KRShowa University · JP

Funding

Vsx2 Dependent Regulation of Retinal Progenitor Cell PropertiesR01EY013760 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LEVINE, EDWARD M · 2003 to 2024
$6.9M
Training Program in Quantitative Ocular GenomicsT32EY021453 · NEI · VANDERBILT UNIVERSITY · PI BRANTLEY, MILAM A, COX, NANCY J · 2011 to 2020
$1.4M
NEI NIH HHS R01 EY013760NEI NIH HHS T32 EY021453
6 · The paper itself

Abstract

The visual responses of vertebrates are sensitive to the overall composition of retinal interneurons including amacrine cells, which tune the activity of the retinal circuitry. The expression of

Indexed as

Enhancer Elements, GeneticGene Expression RegulationAdaptation, OcularAnimalsCytoskeletal ProteinsDNA-Binding ProteinsLIM Domain ProteinsLIM-Homeodomain ProteinsMiceMice, KnockoutPAX6 Transcription FactorRetinaTranscription FactorsCytoskeletal ProteinsDNA-Binding Proteinsinsulin gene enhancer binding protein Isl-1Lhx3 proteinLIM Domain ProteinsLIM-Homeodomain ProteinsPax6 protein, mousePAX6 Transcription FactorTgfb1i1 protein, mouseTranscription Factorscell fate determinationchromosomesgenesLIM domain proteinmouseneurosciencePax6retinavisual adaptation

Identifiers

PMID28139974
PMCPMC5308899
OpenAlexW2584009354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.