Evidence map›Paper›PMID 28139757›Full record

ArticleProstate cancer and prostatic diseases2017

Establishing the distribution of satellite lesions in intermediate- and high-risk prostate cancer: implications for focused radiotherapy.

J V Hegde, D J Margolis, P-C Wang, R E Reiter, J Huang, M L Steinberg, M Kamrava

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PubMed Full text at PMC Publisher
In one paragraph

Article in Prostate cancer and prostatic diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Ablative options for prostate cancer management.Turkish journal of urology · 2021
    Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

J V HegdeDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, USA.
D J MargolisDepartment of Radiology, University of California, Los Angeles, Los Angeles, CA, USA.
P-C WangDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, USA.
R E ReiterDepartment of Urology, University of California, Los Angeles, Los Angeles, CA, USA.
J HuangDepartment of Pathology, Duke University Medical Center, Durham, NC, USA.
M L SteinbergDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, USA.
M KamravaDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, USA.

Funding

UCLA SPORE IN PROSTATE CANCERP50CA092131 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREEMAN, MICHAEL R · 2002 to 2023
$42.6M
NCI NIH HHS P50 CA092131
6 · The paper itself

Abstract

backgroundIn focused radiotherapy for prostate cancer (PC), a full dose of radiation is delivered to the index lesion while reduced dose is delivered to the remaining prostate to reduce morbidity. As PC is commonly multifocal, we investigated whether baseline clinical characteristics or multiparametric magnetic resonance imaging (mpMRI) may be useful to predict the actual pathologic distribution of PC in men with intermediate- or high-risk PC, which may better inform how to deliver focused radiotherapy.

methodsA retrospective single-institutional study was performed on 71 consecutive men with clinically localized, intermediate- or high-risk PC who underwent mpMRI followed by radical prostatectomy (RP) from January 2012 to December 2012. Logistic regression analysis was performed to evaluate preoperative predictors for satellite lesions. Performance characteristics of mpMRI to detect satellite lesions and the extent of prostate disease (one hemi-gland vs both) were also evaluated.

resultsIn all, 50.7% had satellite lesions on mpMRI. On RP specimen analysis, 66.2% had satellite lesions and 55.3% of these satellite lesions had pathologic Gleason score (pGS)⩾3+4. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy for mpMRI detecting a satellite lesion being present in the RP specimen were 59.6%, 66.7%, 77.8%, 45.7% and 62.0%, respectively. The presence of MRI satellite lesions was the only preoperative predictor significantly associated with finding satellite lesions on final pathology (hazard ratio (HR), 2.95, P=0.040). There was agreement in 76.1% of the entire cohort for unilateral vs bilateral disease when incorporating both biopsy and mpMRI information and comparing with the RP specimen.

conclusionsIn intermediate risk or greater PC, only the presence of mpMRI satellite lesions could predict for pathologic satellite lesions. While combining biopsy and mpMRI information may improve preoperative disease localization, the relatively high incidence of bilateral hemi-gland involvement with pGS ⩾7 satellite lesions makes it challenging to appropriately select men eligible for hemi-gland therapy.

Indexed as

Magnetic Resonance ImagingAgedBiopsyHumansMaleMiddle AgedProstateProstatectomyProstatic NeoplasmsRetrospective StudiesRisk Assessment

Identifiers

PMID28139757
PMCPMC6946385

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