Evidence map›Paper›PMID 28139736›Full record

ArticleScientific reports2017

Young Bone-Marrow Sca-1

Shu-Hong Li, Lu Sun, Lei Yang, Jiao Li, Zhengbo Shao, Guo-Qing Du, Jun Wu, Richard D Weisel, Ren-Ke Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Comparative Study onStem cells international · 2018
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shu-Hong LiDivision of Cardiovascular Surgery, Toronto General Research Institute, University Health Network, Toronto, ON, Canada.
Lu SunDivision of Cardiovascular Surgery, Toronto General Research Institute, University Health Network, Toronto, ON, Canada.
Lei YangDivision of Cardiovascular Surgery, Toronto General Research Institute, University Health Network, Toronto, ON, Canada.
Jiao LiDivision of Cardiovascular Surgery, Toronto General Research Institute, University Health Network, Toronto, ON, Canada.
Zhengbo ShaoDivision of Cardiovascular Surgery, Toronto General Research Institute, University Health Network, Toronto, ON, Canada.
Guo-Qing DuDivision of Cardiovascular Surgery, Toronto General Research Institute, University Health Network, Toronto, ON, Canada.
Jun WuDivision of Cardiovascular Surgery, Toronto General Research Institute, University Health Network, Toronto, ON, Canada.
Richard D WeiselDivision of Cardiovascular Surgery, Toronto General Research Institute, University Health Network, Toronto, ON, Canada.
Ren-Ke LiDivision of Cardiovascular Surgery, Toronto General Research Institute, University Health Network, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone marrow (BM) reconstitution with young BM cells in aged recipients restores the functionality of cardiac resident BM-derived progenitors. This study investigated the cell type primarily responsible for this effect. We reconstituted old mice with BM cells from young or old mice and found that the number of stem cell antigen 1 (Sca-1) cells homing to the heart was significantly greater in young than old chimeras. We then reconstituted old mice with young BM Sca-1

Indexed as

Age FactorsAnimalsAntigens, LyBone Marrow CellsCell MovementCell ProliferationCyclin-Dependent Kinase Inhibitor p27Graft SurvivalHematopoietic Stem CellsHematopoietic Stem Cell TransplantationMembrane ProteinsMiceMyocardial InfarctionMyocardiumNeovascularization, PathologicProto-Oncogene Proteins c-aktAntigens, LyCyclin-Dependent Kinase Inhibitor p27Ly6a protein, mouseMembrane ProteinsProto-Oncogene Proteins c-aktReceptor, Platelet-Derived Growth Factor beta

Identifiers

PMID28139736
PMCPMC5282531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.