ArticleScientific reports2017
Adaptor Protein 2 (AP-2) complex is essential for functional axogenesis in hippocampal neurons.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 18 citations in OpenAlex.
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- Article
- TBC1D24 regulates axonal outgrowth and membrane trafficking at the growth cone in rodent and human neurons.Cell death and differentiation · 2019Article
- Loss of Neurofascin-186 Disrupts Alignment of AnkyrinG Relative to Its Binding Partners in the Axon Initial Segment.Frontiers in cellular neuroscience · 2019Article
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
The complexity and diversity of a neural network requires regulated elongation and branching of axons, as well as the formation of synapses between neurons. In the present study we explore the role of AP-2, a key endocytic adaptor protein complex, in the development of rat hippocampal neurons. We found that the loss of AP-2 during the early stage of development resulted in impaired axon extension and failed maturation of the axon initial segment (AIS). Normally the AIS performs two tasks in concert, stabilizing neural polarity and generating action potentials. In AP-2 silenced axons polarity is established, however there is a failure to establish action potential firing. Consequently, this impairs activity-driven Ca
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