ArticleScientific reports2017
The PRC2-binding long non-coding RNAs in human and mouse genomes are associated with predictive sequence features.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The lncRNA DUBR is regulated by CTCF and coordinates chromatin landscape and gene expression in hematopoietic cells.Nucleic acids research · 2025Article
- Differential Expression of Long Noncoding RNAs in Murine Myoblasts After Short Hairpin RNA-Mediated Dysferlin Silencing In Vitro: Microarray Profiling.JMIR bioinformatics and biotechnology · 2022Article
- MEG8 regulates Tissue Factor Pathway Inhibitor 2 (TFPI2) expression in the endothelium.Scientific reports · 2022Article
- Tunable, division-independent control of gene activation timing by a polycomb switch.Cell reports · 2021Article
- Functional Interaction among lncRNA HOTAIR and MicroRNAs in Cancer and Other Human Diseases.Cancers · 2021Review
- Pseudogenes: A Novel Source of Trans-Acting Antisense RNAs.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Genome-wide analysis of long noncoding RNAs, 24-nt siRNAs, DNA methylation and H3K27me3 marks in Brassica rapa.PloS one · 2021Article
- Linking diabetic vascular complications with LncRNAs.Vascular pharmacology · 2019Review
- BMAL1 associates with chromosome ends to control rhythms in TERRA and telomeric heterochromatin.PloS one · 2019Article
- Long noncoding RNAProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Epigenomes in Cardiovascular Disease.Circulation research · 2018Review
- RNA-mediated regulation of heterochromatin.Current opinion in cell biology · 2017Review
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Authors and funding
3 authors.
Funding
Abstract
Recently, long non-coding RNAs (lncRNAs) have emerged as an important class of molecules involved in many cellular processes. One of their primary functions is to shape epigenetic landscape through interactions with chromatin modifying proteins. However, mechanisms contributing to the specificity of such interactions remain poorly understood. Here we took the human and mouse lncRNAs that were experimentally determined to have physical interactions with Polycomb repressive complex 2 (PRC2), and systematically investigated the sequence features of these lncRNAs by developing a new computational pipeline for sequences composition analysis, in which each sequence is considered as a series of transitions between adjacent nucleotides. Through that, PRC2-binding lncRNAs were found to be associated with a set of distinctive and evolutionarily conserved sequence features, which can be utilized to distinguish them from the others with considerable accuracy. We further identified fragments of PRC2-binding lncRNAs that are enriched with these sequence features, and found they show strong PRC2-binding signals and are more highly conserved across species than the other parts, implying their functional importance.
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