ArticleScientific reports2017
Development of polymer based cryogel matrix for transportation and storage of mammalian cells.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 48 citations in OpenAlex.
- CFD Mechanistic Modeling of a Monolithic Chromatography System: Challenges and Opportunities.ACS omega · 2026Review
- Cryogels with controllable physico-chemical properties as advanced delivery systems for biomedical applications.Materials today. Bio · 2025Review
- Versatility of the Preparation Method for Macroporous Cryogel Particles Utilizing the Inverse Leidenfrost Effect.ACS omega · 2023Article
- An Overview on Collagen and Gelatin-Based Cryogels: Fabrication, Classification, Properties and Biomedical Applications.Polymers · 2021Review
- Injectable Cryogels in Biomedicine.Gels (Basel, Switzerland) · 2021Review
- Trends in Monoclonal Antibody Production Using Various Bioreactor Syst.Journal of microbiology and biotechnology · 2021Review
- Development of Scaffolds with Adjusted Stiffness for Mimicking Disease-Related Alterations of Liver Rigidity.Journal of functional biomaterials · 2020Article
- Bioglass-Incorporated Methacrylated Gelatin Cryogel for Regeneration of Bone Defects.Polymers · 2018Article
- Injectable Hyaluronic Acid-Materials (Basel, Switzerland) · 2018Article
- A collagen based cryogel bioscaffold coated with nanostructured polydopamine as a platform for mesenchymal stem cell therapy.Journal of biomedical materials research. Part A · 2018Article
- An oxygen plasma treated poly(dimethylsiloxane) bioscaffold coated with polydopamine for stem cell therapy.Journal of materials science. Materials in medicine · 2018Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the potential of polymeric cryogel matrices such as 2-hydroxyethyl methacrylate (HEMA)-agarose (HA) and gelatin matrix as a transporting and storage material for mammalian cells. Both the HA and gelatin matrices were found to possess a homogenous distribution of pores as shown by scanning electron microscopic (SEM) images and flow rate of 8 and 5 mL/min, respectively. In the case of HA cryogel, after 5 days of simulated transportation, C2C12 cells kept in cryogel matrix showed higher percentage viability (89%) as compared to 64.5% viability of cells kept in suspension culture. The cells recovered from the HA cryogel were able to proliferate as revealed by the microscopic analysis. In the case of gelatin cryogel, it was shown that C2C12 cells seeded on the cryogel under simulated transportation condition were found to proliferate over the period of 5 days. It was also observed that the cells after simulation can be cryopreserved and the duration of cryopreservation does not affect their viability. Furthermore, gelatin cryogel was used for cryopreservation of HepG2 and HUVEC cells to extend the system for other cell types. These results show the potential of cryogels as efficient, low-cost transporting matrix at room temperature and in cryo-conditions.
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