ArticleScientific reports2017
Evaluation of the Bone-ligament and tendon insertions based on Raman spectrum and its PCA and CLS analysis.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- From physical modalities to energy-responsive biomaterials: Current strategies and challenges in tendon-to-bone healing.Bioactive materials · 2026Review
- Application and optimization of bioengineering strategies in facilitating tendon-bone healing.Biomedical engineering online · 2025Review
- Bioinspired piezoelectric patch design for sonodynamic therapy: a preclinical mechanistic evaluation of rotator cuff repair and functional regeneration.Frontiers in bioengineering and biotechnology · 2025Article
- Bone marrow mesenchymal stem cell-derived exosomal microRNAs target PI3K/Akt signaling pathway to promote the activation of fibroblasts.World journal of stem cells · 2023Article
- Raman Spectroscopy in Skeletal Tissue Disorders and Tissue Engineering: Present and Prospective.Tissue engineering. Part B, Reviews · 2022Review
- PCA-based sub-surface structure and defect analysis for germanium-on-nothing using nanoscale surface topography.Scientific reports · 2022Article
- Biomimetic strategies for tendon/ligament-to-bone interface regeneration.Bioactive materials · 2021Review
- Vibrational spectroscopy of liquid biopsies for prostate cancer diagnosis.Therapeutic advances in medical oncology · 2020Article
- Article
- Raman spectroscopy uncovers biochemical tissue-related features of extracellular vesicles from mesenchymal stromal cells.Scientific reports · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Injuries to the Anterior Cruciate Ligament (ACL) and Rotator Cuff Tendon (RCT) are common in physically active and elderly individuals. The development of an artificial prosthesis for reconstruction/repair of ACL and RCT injuries is of increasing interest due to the need for viable tissue and reduced surgically-related co-morbidity. An optimal prosthesis design is still elusive, therefore an improved understanding of the bone-soft tissue interface is extremely urgent. In this work, Raman spectral mapping was used to analyze, at the micron level, the chemical composition and corresponding structure of the bone-soft tissue interface. Raman spectroscopic mapping was performed using a Raman spectrometer with a 785 nm laser coupled to a microscope. Line-mapping procedure was performed on the ACL and RCT bone insertion sites. The classical least squares (CLS) fitting model was created from reference spectra derived from pure bone and soft-tissue components, and spectral maps collected at multiple sites from ACL and RCT specimens. The results suggest that different source of interface shows different boundary, even they seems have the same components. Compared to the common histology results, it provided intact molecular information that can easily distinguished some relative component change.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.