Evidence map›Paper›PMID 28139654›Full record

ArticleNature cell biology2017

CPEB4 links the clock and the UPR to protect the liver.

Paul C Moore, Scott A Oakes

Abstract readNewsComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Is Alzheimer's Disease a Liver Disease of the Brain?Journal of Alzheimer's disease : JAD · 2020
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Paul C MooreDepartment of Pathology, Diabetes Center, and Helen Diller Family Comprehensive Cancer Center at the University of California, San Francisco, California 94143, USA.
Scott A OakesDepartment of Pathology, Diabetes Center, and Helen Diller Family Comprehensive Cancer Center at the University of California, San Francisco, California 94143, USA.

Funding

Signaling Cell Death from the Endoplasmic ReticulumR01CA136577 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OAKES, SCOTT A. · 2009 to 2013
$1.6M
Attenuating ER and oxidative stress signaling to reduce cell degeneration in vivoR01DK095306 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OAKES, SCOTT A., PAPA, FEROZ R · 2013 to 2016
$1.5M
Molecular Pathology of CancerT32CA177555 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BASTIAN, BORIS C., OAKES, SCOTT A. · 2013 to 2017
$1.1M
NCI NIH HHS R01 CA136577NCI NIH HHS T32 CA177555NIDDK NIH HHS R01 DK095306
6 · The paper itself

Abstract

Under misfolded protein stress, the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to restore homeostasis, or commits the cell to apoptosis. A study now uncovers how the UPR is governed by the circadian clock to adjust ER protein-folding capacity to metabolic demand and protect against liver damage.

Indexed as

AnimalsEndoplasmic ReticulumEndoplasmic Reticulum StressHomeostasisHumansLiverRNA-Binding ProteinsUnfolded Protein ResponseCPEB4 protein, humanRNA-Binding Proteins

Identifiers

PMID28139654
PMCPMC5555618

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.