ArticleNature communications2017
Experimental evidence for circular inference in schizophrenia.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 129 citations in OpenAlex.
- Premature commitment to uncertain decisions during human NMDA receptor hypofunction.Nature communications · 2022Trial
- A Dual Prediction Error Populations Model of Schizophrenia Spectrum Disorders: Bridging NMDA Hypofunction and Gain Hyperfunction.Schizophrenia bulletin · 2026Article
- A corticostriatal circuit updates subjective beliefs about latent task states.bioRxiv : the preprint server for biology · 2026Article
- Article
- Mesocorticostriatal Reinforcement Learning of State Representation and Value with Implications for the Mechanisms of Schizophrenia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Task learning increases information redundancy of neural responses in macaque visual cortex.Science (New York, N.Y.) · 2026Article
- Beyond the reducing valve: towards a computational neurophenomenology of altered states via deep neural networks.Frontiers in psychology · 2026Article
- Reduced weighting of short-term perceptual priors during auditory perceptual decision-making in psychosis-prone individuals.BMC biology · 2025Article
- Article
- N-methyl-d-aspartate receptor hypofunction causes recurrent and transient failures of perceptual inference.Brain : a journal of neurology · 2025Article
- A detailed theory of thalamic and cortical microcircuits for predictive visual inference.Science advances · 2025Article
- Language-based inference generation under working memory load: the role of schizotypal traits in jumping to conclusions.Frontiers in psychiatry · 2025Article
- A dissociation between the use of implicit and explicit priors in perceptual inference.Communications psychology · 2024Article
- Individual differences in belief updating and phasic arousal are related to psychosis proneness.Communications psychology · 2024Article
- Multisensory perceptual and causal inference is largely preserved in medicated post-acute individuals with schizophrenia.PLoS biology · 2024Article
- Conspiracy beliefs and perceptual inference in times of political uncertainty.Scientific reports · 2024Article
- A new predictive coding model for a more comprehensive account of delusions.The lancet. Psychiatry · 2024Review
- Applying a clinical staging model in patients affected by schizophrenia spectrum disorder.Frontiers in psychiatry · 2024Article
- Voltage-gated potassium channels as a potential therapeutic target for the treatment of neurological and psychiatric disorders.Frontiers in cellular neuroscience · 2024Review
- Sensory processing in humans and mice fluctuates between external and internal modes.PLoS biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia (SCZ) is a complex mental disorder that may result in some combination of hallucinations, delusions and disorganized thinking. Here SCZ patients and healthy controls (CTLs) report their level of confidence on a forced-choice task that manipulated the strength of sensory evidence and prior information. Neither group's responses can be explained by simple Bayesian inference. Rather, individual responses are best captured by a model with different degrees of circular inference. Circular inference refers to a corruption of sensory data by prior information and vice versa, leading us to 'see what we expect' (through descending loops), to 'expect what we see' (through ascending loops) or both. Ascending loops are stronger for SCZ than CTLs and correlate with the severity of positive symptoms. Descending loops correlate with the severity of negative symptoms. Both loops correlate with disorganized symptoms. The findings suggest that circular inference might mediate the clinical manifestations of SCZ.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.