Evidence map›Paper›PMID 28139543›Full record

ArticleThe Indian journal of medical research2016

Antibiotic resistance & pathogen profile in ventilator-associated pneumonia in a tertiary care hospital in India.

Abhijit Chaudhury, A Shobha Rani, Usha Kalawat, Sachin Sumant, Anju Verma, B Venkataramana

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Indian journal of medical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Nosocomial Infections and Role of Nanotechnology.Bioengineering (Basel, Switzerland) · 2022
    Review
  3. Article
  4. Article
  5. Health care-associated infections - an overview.Infection and drug resistance · 2018
    Review
  6. Authors' Response.The Indian journal of medical research · 2017
    Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Abhijit ChaudhuryDepartment of Microbiology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India.
A Shobha RaniDepartment of Microbiology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India.
Usha KalawatDepartment of Microbiology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India.
Sachin SumantDepartment of Microbiology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India.
Anju VermaDepartment of Microbiology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India.
B VenkataramanaDepartment of Microbiology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India.
Sri Venkateswara Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

objectivesVentilator-associated pneumonia (VAP) is an important hospital-acquired infection with substantial mortality. Only a few studies are available from India addressing the microbiological aspects of VAP, which have been done with small study populations. This study was carried out in the intensive care units (ICUs) of a tertiary care hospital to assess the profile of pathogens and to determine the pattern of antimicrobial resistance.

methodsThis was a retrospective study of clinically suspected cases of VAP. Over a three year period, a total of 247 cases in 2011, 297 in 2012 and 303 in 2013 admitted in ICUs on mechanical ventilation with clinical evidence of VAP were included in our study. The endotracheal aspirate samples from these suspected cases were subjected to quantitative culture technique, and colony count of ≥10[5] colony forming units/ml was considered significant. Antimicrobial susceptibility test for the isolates was done.

resultsVAP rates of 44.1, 43.8 and 26.3 were seen in 2011, 2012 and 2013, respectively. In all the three years, non-fermentative Gram-negative bacilli were the predominant organisms, followed by Pseudomonas spp. and Klebsiella spp. Staphylococcus aureus exhibited a downwards trend in prevalence from 50.0 per cent in 2011 to 34.9 per cent in 2013. An increase in vancomycin-resistant enterococci was seen from 4.3 per cent in 2012 to 8.3 per cent in 2013, while methicillin resistance amongst the S. aureus crossed the 50 per cent mark in 2013. An increasing trend in resistance was shown by Pseudomonas spp. for piperacillin-tazobactam (PTZ), amikacin and imipenem (IPM). For the non-fermenters, resistance frequency remained very high except for IPM (33.1%) and polymyxin-B (2.4%). INTERPRETATION &

conclusionsOur findings show VAP as an important problem in the ICU setting. The incidence of multidrug-resistant pathogens was on the rise. The resistance pattern of these pathogens can help an institution to formulate effective antimicrobial policy. To have a comprehensive pan-India picture, multicentric studies are needed.

Indexed as

Drug Resistance, Multiple, BacterialMethicillin ResistanceAmikacinHumansImipenemIndiaIntensive Care UnitsKlebsiellaPenicillanic AcidPiperacillinPiperacillin, Tazobactam Drug CombinationPneumonia, Ventilator-AssociatedPseudomonasStaphylococcus aureusTertiary Care CentersVancomycin-Resistant EnterococciAmikacinImipenemPenicillanic AcidPiperacillinPiperacillin, Tazobactam Drug Combination

Identifiers

PMID28139543
PMCPMC5320850
OpenAlexW2575148395

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.