ArticleSaudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
Therapeutic efficacy of an elemental diet for patients with crohn's disease and its association with amino acid metabolism.
Article in Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Partial Enteral Nutrition in the Management of Crohn's Disease: A Systematic Review and Meta-Analysis.Journal of Crohn's & colitis · 2025Pooled it
- Nutrition management and self-perceived relapse triggers in patients with inflammatory bowel disease: results from the 3R web-based survey.Crohn's & colitis 360 · 2026Article
- The Effect of Protein Nutritional Support on Inflammatory Bowel Disease and Its Potential Mechanisms.Nutrients · 2024Review
- Human Gut Microbiome Transplantation in Ileitis Prone Mice: A Tool for the Functional Characterization of the Microbiota in Inflammatory Bowel Disease Patients.Inflammatory bowel diseases · 2020Article
- Elemental Diet Enriched with Amino Acids Alleviates Mucosal Inflammatory Response and Prevents Colonic Epithelial Barrier Dysfunction in Mice with DSS-Induced Chronic Colitis.Journal of immunology research · 2020Article
- Opening a Window on Attention: Adjuvant Therapies for Inflammatory Bowel Disease.Canadian journal of gastroenterology & hepatology · 2020Review
- Construction and Analysis of Human Diseases and Metabolites Network.Frontiers in bioengineering and biotechnology · 2020Article
- Plasma-Free Amino Acid Profiles in Crohn's Disease: Relationship With the Crohn Disease Activity Index.Clinical medicine insights. Gastroenterology · 2018Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimWe investigated the association between blood amino acid concentration changes caused by elemental diet (ED) and their relationship to its therapeutic effect. PATIENTS AND
methodsPatients with active Crohn's disease (CD) followed ED for 12 weeks. Patients not previously treated with ED were defined as new ED, and those with previous ED therapy (≥900 kcal/day) were defined as previous ED. Disease activity markers [Crohn's disease activity index (CDAI) and C-reactive protein (CRP) level], blood biochemistry test results, and plasma amino acid concentrations were measured before and after the treatment.
resultsHistidine (His), tryptophan (Trp), valine (Val), and methionine (Met) increased after the treatment in the 17 patients with clinical remission, however, no increase occurred in plasma amino acid concentrations in the 8 patients without remission. The multivariate index using AminoIndex™technology (MIAI) was correlated with the CDAI (r = 0.475,P < 0.001), and it decreased as patients' conditions improved during the treatment. All patients in the new ED group (n = 11) exhibited increases in the nutritional indices, albumin level, and body mass index after treatment, as well as increased levels of His, Trp, Val, and phenylalanine. None of these changes were observed in the previous ED group (n = 14).
conclusionsPlasma amino acid concentrations and MIAI may provide useful noninvasive markers for evaluating disease activity and response to treatment. ED was effective in improving disease activity, nutritional status, and plasma amino acid levels, and thus it may be particularly effective for poorly nourished patients with CD who have not previously undergone this treatment.
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