ArticleNutrition, metabolism, and cardiovascular diseases : NMCD2017
CPT1A methylation is associated with plasma adiponectin.
Article in Nutrition, metabolism, and cardiovascular diseases : NMCD, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005129 (The Bogalusa Heart Study), which is not on this map. Cited by 14 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Bogalusa Heart Study
Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- DNA methylation of genes involved in lipid metabolism drives adiponectin levels and metabolic disease.Diabetologia · 2026Pooled it
- A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids.Nature communications · 2021Pooled it
- DNA methylation of blood cells is associated with prevalent type 2 diabetes in a meta-analysis of four European cohorts.Clinical epigenetics · 2021Pooled it
- Trial
- Epigenome-wide analysis in West Africans identifies DNA methylation markers for circulating adiponectin.EBioMedicine · 2026Article
- Mitochondrial CPT1A: Insights into structure, function, and basis for drug development.Frontiers in pharmacology · 2023Review
- DNA methylation signatures associated with cardiometabolic risk factors in children from India and The Gambia: results from the EMPHASIS study.Clinical epigenetics · 2022Article
- Article
- Lipid Phenotypes and DNA Methylation: a Review of the Literature.Current atherosclerosis reports · 2021Review
- A 6-CpG validated methylation risk score model for metabolic syndrome: The HyperGEN and GOLDN studies.PloS one · 2021Article
- Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems.Epigenomics · 2020Article
- The challenge of detecting genotype-by-methylation interaction: GAW20.BMC genetics · 2018Article
- DNA methylation in human lipid metabolism and related diseases.Current opinion in lipidology · 2018Review
- Metabolic and inflammatory biomarkers are associated with epigenetic aging acceleration estimates in the GOLDN study.Clinical epigenetics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 5 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsAdiponectin, an adipose-secreted protein that has been linked to insulin sensitivity, plasma lipids, and inflammatory patterns, is an established biomarker for metabolic health. Despite clinical relevance and high heritability, the determinants of plasma adiponectin levels remain poorly understood. METHODS AND
resultsWe conducted the first epigenome-wide cross-sectional study of adiponectin levels using methylation data on 368,051 cytosine-phosphate-guanine (CpG) sites in CD4+ T-cells from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN, n = 991). We fit linear mixed models, adjusting for age, sex, study site, T-cell purity, and family. We have identified a positive association (regression coefficient ± SE = 0.01 ± 0.001, P = 3.4 × 10
conclusionWe have identified and replicated associations between several biologically plausible loci and plasma adiponectin. These findings support the importance of epigenetic processes in metabolic traits, laying the groundwork for future translational applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.