ArticleeLife2017
Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 1 pooled it
8.0field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
91 citing papers in PubMed, 1 synthesis or guideline pooled it, 176 citations in OpenAlex.
- A multifaceted approach for analyzing complex phenotypic data in rodent models of autism.Molecular autism · 2019Pooled it
- A randomized controlled trial of intranasal oxytocin in Phelan-McDermid syndrome.Molecular autism · 2021Trial
- Neural modulation of social reinforcement learning by intranasal oxytocin in male adults with high-functioning autism spectrum disorder: a randomized trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Trial
- HPSC-derived mesenchymal stromal cells ameliorate murine autistic-like phenotypes through activating oxytocinergic neurons.Science advances · 2026Article
- Preserved social development but impaired executive function in aResearch square · 2026Article
- Oxytocin Variants Induce Cellular Signaling and Neurite Outgrowth in Human-Derived Neuron-like SH-SY5Y Cell Line.NeuroSci · 2026Article
- The emerging role of gene therapy in autism spectrum disorder.Discover mental health · 2026Review
- Heightened empathic responses led by imbalanced cortico-amygdala circuit inbioRxiv : the preprint server for biology · 2025Article
- Multi-connectomics underpin emotional dysfunction in mouse exposed to simulated space composite environment.Translational psychiatry · 2025Article
- Oxytocin signaling regulates maternally directed behavior during early life.Science (New York, N.Y.) · 2025Article
- HCAR3 May Mediate Autism Symptoms: Evidence From RNA-Sequencing of Peripheral Blood Mononuclear Cells.Psychiatry investigation · 2025Article
- Brain-wide connectivity and novelty response of the dorsal endopiriform nucleus in mice.Cell reports · 2025Article
- Developmental Disturbances in Animal Models of Autism Spectrum Disorder.Developmental neurobiology · 2025Review
- Complexity of the Hypothalamic Oxytocin System and its Involvement in Brain Functions and Diseases.Neuroscience bulletin · 2025Review
- Altered Neural Activity in the Mesoaccumbens Pathway Underlies Impaired Social Reward Processing in Shank3-Deficient Rats.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Oxytocin improves maternal licking behavior deficits in autism-associated Shank3 mutant dogs.Translational psychiatry · 2025Article
- Hippocampus Oxytocin Signaling Promotes Prosocial Eating in Rats.Biological psychiatry · 2025Article
- Acute, chronic and conditioned effects of intranasal oxytocin in the mu-opioid receptor knockout mouse model of autism: Social context matters.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Selective vulnerability of parvocellular oxytocin neurons in social dysfunction.Nature communications · 2024Article
- Assessing sociability using the Three-Chamber Social Interaction Test and the Reciprocal Interaction Test in a genetic mouse model of ASD.Behavioral and brain functions : BBF · 2024Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 2 countries.
Hala Harony-NicolasSeaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, United States.ORCID 0000-0001-8283-9093
Maya KaySagol Department of Neurobiology, University of Haifa, Haifa, Israel.
Johann du HoffmannSeaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, United States.
Matthew E KleinDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, United States.
Ozlem Bozdagi-GunalSeaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, United States.
Mohammed RiadSeaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, United States.
Nikolaos P DaskalakisDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, United States.
Sankalp SonarSeaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, United States.
Pablo E CastilloDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, United States.
Patrick R HofSeaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, United States.
Matthew L ShapiroFriedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, United States.
Mark G BaxterFriedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, United States.
Shlomo WagnerSagol Department of Neurobiology, University of Haifa, Haifa, Israel.ORCID 0000-0002-7618-0752
Joseph D BuxbaumSeaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, United States.ORCID 0000-0001-8898-8313
Allen Institute for Brain Science · USIcahn School of Medicine at Mount Sinai · USAlbert Einstein College of Medicine · USUniversity of Haifa · IL
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · NIGMS · YESHIVA UNIVERSITY · PI AKABAS, MYLES H. · 1985 to 2022
$35.6MProspective memory coding by the hippocampusR01MH073689 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SHAPIRO, MATTHEW L · 2006 to 2022
$5.7MPresynaptic Forms of Long-Term Plasticity in the CNSR01DA017392 · NIDA · YESHIVA UNIVERSITY · PI CASTILLO, PABLO E · 2003 to 2019
$4.5MActivity-dependent synaptic plasticity expressed by NMDARsR01MH081935 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CASTILLO, PABLO E · 2008 to 2018
$4.0MIdentifying therapeutic targets for autism using Shank3-deficient miceR01MH093725 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BUXBAUM, JOSEPH D. · 2011 to 2015
$2.5MPrefrontal function in the Shank3-deficient rat: A first rat model for ASDR01MH101584 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BUXBAUM, JOSEPH D., HOF, PATRICK R · 2014 to 2018
$2.4MThe Role of Sam68 in Synaptic Transmission and PlasticityF31NS073200 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI KLEIN, MATTHEW · 2011 to 2014
$157kNIDA NIH HHS R01 DA017392NIGMS NIH HHS T32 GM007288NIMH NIH HHS R01 MH073689NIMH NIH HHS R01 MH081935NIMH NIH HHS R01 MH093725NIMH NIH HHS R01 MH101584NINDS NIH HHS F31 NS073200
Abstract
Mutations in the synaptic gene
Indexed as
AnimalsBehavior, AnimalChromosome DeletionChromosome DisordersChromosomes, Human, Pair 22Disease Models, AnimalHippocampusNerve Tissue ProteinsOxytocinPrefrontal CortexRatsSocial BehaviorNerve Tissue ProteinsOxytocinShank3 protein, ratattentionautism spectrum disorderneuroscienceoxytocinPhelan McDermid SyndromeratShank3social behavior
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.