Evidence map›Paper›PMID 28139123›Full record

ArticleAnalytical chemistry2016

Biomonitoring DNA Adducts of Cooked Meat Carcinogens in Human Prostate by Nano Liquid Chromatography-High Resolution Tandem Mass Spectrometry: Identification of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine DNA Adduct.

Shun Xiao, Jingshu Guo, Byeong Hwa Yun, Peter W Villalta, Suprita Krishna, Resha Tejpaul, Paari Murugan, Christopher J Weight, Robert J Turesky

Abstract readValidation Study
In one paragraph

Article in Analytical chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 58 citations in OpenAlex.

  1. Frequent Detection of Abasic Sites andChemical research in toxicology · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Metabolism and biomarkers of heterocyclic aromatic amines in humans.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021
    Review
  9. Article
  10. Article
  11. Applying Tobacco, Environmental, and Dietary-Related Biomarkers to Understand Cancer Etiology and Evaluate Prevention Strategies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Shun XiaoMasonic Cancer Center and ‡Department of Medicinal Chemistry, University of Minnesota , 2231 Sixth Street SE, Minneapolis, Minnesota 55455, United States.
Jingshu GuoMasonic Cancer Center and ‡Department of Medicinal Chemistry, University of Minnesota , 2231 Sixth Street SE, Minneapolis, Minnesota 55455, United States.
Byeong Hwa YunMasonic Cancer Center and ‡Department of Medicinal Chemistry, University of Minnesota , 2231 Sixth Street SE, Minneapolis, Minnesota 55455, United States.
Peter W VillaltaMasonic Cancer Center and ‡Department of Medicinal Chemistry, University of Minnesota , 2231 Sixth Street SE, Minneapolis, Minnesota 55455, United States.
Suprita KrishnaMasonic Cancer Center and ‡Department of Medicinal Chemistry, University of Minnesota , 2231 Sixth Street SE, Minneapolis, Minnesota 55455, United States.
Resha TejpaulMasonic Cancer Center and ‡Department of Medicinal Chemistry, University of Minnesota , 2231 Sixth Street SE, Minneapolis, Minnesota 55455, United States.
Paari MuruganMasonic Cancer Center and ‡Department of Medicinal Chemistry, University of Minnesota , 2231 Sixth Street SE, Minneapolis, Minnesota 55455, United States.
Christopher J WeightMasonic Cancer Center and ‡Department of Medicinal Chemistry, University of Minnesota , 2231 Sixth Street SE, Minneapolis, Minnesota 55455, United States.
Robert J TureskyMasonic Cancer Center and ‡Department of Medicinal Chemistry, University of Minnesota , 2231 Sixth Street SE, Minneapolis, Minnesota 55455, United States.ORCID 0000-0001-7355-9903
University of Minnesota · US

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Jeffrey S. Miller · 1998 to 2026
$100.4M
Chemical markers of heterocyclic aromatic amines for human biomonitoringR01CA122320 · NCI · WADSWORTH CENTER · PI TURESKY, ROBERT J. · 2007 to 2018
$4.8M
Mass Spectrometric Analytical Collaborations with Members of the Masonic Cancer Center of the University of MinnesotaR50CA211256 · NCI · UNIVERSITY OF MINNESOTA · PI Peter William Villalta · 2016 to 2026
$2.1M
Carcinogen DNA adduct biomarkers in formalin fixed tissuesR33CA186795 · NCI · UNIVERSITY OF MINNESOTA · PI TURESKY, ROBERT J. · 2014 to 2016
$982k
NCI NIH HHS P30 CA077598NCI NIH HHS R01 CA122320NCI NIH HHS R33 CA186795NCI NIH HHS R50 CA211256
6 · The paper itself

Abstract

Epidemiologic studies have reported an association between frequent consumption of well-done cooked meats and prostate cancer risk. However, unambiguous physiochemical markers of DNA damage from carcinogens derived from cooked meats, such as DNA adducts, have not been identified in human samples to support this paradigm. We have developed a highly sensitive nano-LC-Orbitrap MS

Indexed as

AgedAnimalsCarcinogensCattleChromatography, LiquidCookingDNA AdductsHumansImidazolesLimit of DetectionMaleMeatMiddle AgedProstateQuinoxalinesSmoke2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine2-amino-3,8-dimethylimidazo(4,5-f)quinoxalineCarcinogensDNA AdductsImidazolesQuinoxalinesSmoke

Identifiers

PMID28139123
PMCPMC5545982
OpenAlexW2552402250

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.