SynthesisJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2017
Relationship Between Low Bone Mineral Density and Fractures With Incident Cardiovascular Disease: A Systematic Review and Meta-Analysis.
Synthesis in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed, 1 synthesis or guideline pooled it, 171 citations in OpenAlex.
- Bidirectional association between cardiovascular disease and hip fracture: a systematic review and meta-analysis.BMC cardiovascular disorders · 2025Pooled it
- Body composition and muscle health changes after providing vascular imaging results in older adults: secondary analysis of a randomised controlled trial.Aging clinical and experimental research · 2026Trial
- Effect of salt substitution on fracture-a secondary analysis of the Salt Substitute and Stroke Study (SSaSS).BMC medicine · 2024Trial
- Effect of high-dose vitamin D supplementation on peripheral arterial calcification: secondary analysis of a randomized controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Trial
- Association Between Hemoglobin Glycation Index and Prevalence of Cardiovascular Disease in Middle-Aged and Older Adults With Hip Fracture: Findings From CHARLS and NHANES.Clinical cardiology · 2026Article
- Development of a Machine Learning-Based Triage Score for Medication-Related Osteonecrosis of the Jaw in Osteoporosis Patients Undergoing Tooth Extraction.Diagnostics (Basel, Switzerland) · 2026Article
- Abdominal aortic calcification is associated with hip fracture in the elderly.Scientific reports · 2026Article
- Association between bone health and cardiovascular events in a population-based cohort.Archives of osteoporosis · 2026Observational
- Handgrip Strength and Trajectories of Preclinical Obesity Progression: A Multistate Model Analysis Using the UK Biobank.The Journal of clinical endocrinology and metabolism · 2026Article
- Does Regional Muscle Distribution Predict Functional Capacity? Sex-Specific Insights from Bioimpedance and Performance Testing.Muscles (Basel, Switzerland) · 2026Article
- Osteoporosis and cardiac remodeling in middle-aged and older adults: a cross-sectional study.Scientific reports · 2026Article
- Underlying Mechanisms of Osteoporosis in the Context of Multimorbidity: Clinical Challenges and Management Strategies.Nutrients · 2026Review
- An explainable predictive machine learning model of osteopenia for perimenopausal women based on clinical data: a retrospective single-center study.Frontiers in endocrinology · 2026Article
- Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi-Omics and Multi-Modal Data Analysis.Clinical pharmacology and therapeutics · 2025Article
- Bone and Cardiometabolic Connection: Crosstalk between Osteoporosis and Atherosclerosis.Cell biochemistry and biophysics · 2025Review
- Characterizing the Lipid Profile in Patients with Vertebral or Hip Fragility Fractures: A Hospital-Based Descriptive Study.Journal of clinical medicine · 2025Article
- Quantitative computed tomography provides improved accuracy for diagnosis of lumbar osteoporosis in patients with facet joint osteoarthritis: a cross-sectional study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Associations of subclinical manifestations of coronary and carotid artery atherosclerosis with bone strength parameters in asymptomatic women.Archives of osteoporosis · 2025Article
- The link between osteoporosis and cardiovascular diseases: a review of shared mechanisms, risk factors, and therapeutic approaches.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Review
- Bone mineral density and cardiovascular diseases: a two-sample Mendelian randomization study.JBMR plus · 2025Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 9 institutions in 7 countries.
Funding
Abstract
An increasing evidence base suggests that low bone mineral density (BMD) and fractures are associated with cardiovascular disease (CVD). We conducted a systematic review and meta-analysis summarizing the evidence of low BMD and fractures as risk factors for future CVD. Two independent authors searched major databases from inception to August 1, 2016, for longitudinal studies reporting data on CVD incidence (overall and specific CVD) and BMD status and fractures. The association between low BMD, fractures, and CVD across longitudinal studies was explored by calculating pooled adjusted hazard ratios (HRs) ±95% confidence intervals (CIs) with a random-effects meta-analysis. Twenty-eight studies (18 regarding BMD and 10 fractures) followed a total of 1,107,885 participants for a median of 5 years. Taking those with higher BMD as the reference, people with low BMD were at increased risk of developing CVD during follow-up (11 studies; HR = 1.33; 95%CI, 1.27 to 1.38; I
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.